Hydroxyzine

Hydroxyzine 10mg, 25mg, 50mg

Hydroxyzine is an antihistamine primarily used to alleviate anxiety, tension, and allergic reactions. It works by blocking histamine receptors, resulting in a calming effect and reducing symptoms such as itching, hives, and anxiety. Often prescribed for its sedative properties, Hydroxyzine is commonly used for short-term management of anxiety disorders and as a preoperative sedative, making it a versatile medication in both psychiatric and allergy-related contexts.

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Description

Hydroxyzine is a first-generation antihistamine primarily used to relieve anxiety, itching, and allergy symptoms. It has sedative properties, making it effective for treating anxiety and tension, while also providing relief from allergic reactions.

Uses / Indications

Anxiety and tension relief
Allergic skin reactions such as urticaria (hives)
Preoperative sedation and to decrease anxiety prior to surgery
Prevention and treatment of nausea and vomiting
Insomnia due to anxiety

Dosage and Administration

Adults:
25 mg to 100 mg per day, divided into 3–4 doses depending on the condition being treated.

Children aged 6 years and older:
Dosage typically ranges from 0.5 mg to 1 mg per kg of body weight per day, divided into multiple doses.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Hydroxyzine works by blocking the action of histamine at H1 receptors, which helps alleviate the symptoms of allergic reactions. Additionally, it has effects on the central nervous system, leading to sedation and reduced anxiety.

Side Effects

Common side effects:

Drowsiness
Dry mouth
Dizziness
Fatigue

Rare/serious side effects:

Rapid heartbeat
Severe allergic reactions (rash, swelling, difficulty breathing)
Confusion or agitation

Seek medical attention if serious side effects occur.

Precautions / Warnings

Consult your doctor if you have a history of heart disease, epilepsy, or are pregnant/breastfeeding
Use caution if combining with other medications that can cause sedation
May impair your ability to drive or operate machinery

Drug Interactions

May interact with:

Alcohol (can enhance sedative effects)
Other CNS depressants (e.g., benzodiazepines, opioids)
Monoamine oxidase inhibitors (MAOIs)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

Store at room temperature (20°C–25°C / 68°F–77°F)
Keep away from moisture, heat, and direct light
Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

Extreme drowsiness or lethargy
Fast or irregular heartbeat
Nausea or vomiting
Confusion or agitation

Contact a poison control center or seek emergency medical help immediately.

Contraindications

Allergic to Hydroxyzine or its components
Pregnancy or breastfeeding, unless advised otherwise by a healthcare provider

Brand Names / Alternatives

Atarax
Vistaril
Generic name: Hydroxyzine