Prednisolone

Description

Prednisolone is a corticosteroid medication that is used to treat various inflammatory and autoimmune conditions. It works by suppressing the immune response and reducing inflammation, helping to alleviate symptoms associated with conditions such as allergies, asthma, and arthritis.

Uses / Indications

• Asthma and other respiratory conditions
• Allergic reactions
• Autoimmune diseases (e.g., lupus, rheumatoid arthritis)
• Skin conditions (e.g., eczema, dermatitis)
• Certain cancers (as part of chemotherapy)
• Inflammatory bowel diseases (e.g., Crohn’s disease, ulcerative colitis)

Dosage and Administration

Adults:
Dosage varies widely based on the condition treated, typically ranging from 5 mg to 60 mg daily, with the lowest effective dose being the goal.

Children:
Dosage is determined by the specific condition and body weight, often ranging from 0.1 to 2 mg per kg of body weight per day, divided into multiple doses.

Note: Dosage should always be guided by a healthcare professional.

How It Works (Mechanism of Action)

Prednisolone mimics the effects of hormones produced by the adrenal glands. It modifies the body’s immune response and inflammatory processes by inhibiting the release of substances that trigger inflammation and immune reactions.

Side Effects

Common side effects:

• Increased appetite and weight gain
• Fluid retention and swelling
• Mood changes (e.g., anxiety, euphoria)
• Difficulty sleeping

Rare/serious side effects:

• Severe allergic reactions (rash, swelling, difficulty breathing)
• Signs of infection (fever, chills)
• Adrenal suppression (fatigue, weakness)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Inform your doctor if you have diabetes, liver disease, or a history of mental health issues.
• Use caution when taking this medication long-term, as it can suppress natural steroid production.
• Avoid live vaccines during treatment due to the immune-suppressing effects.

Drug Interactions

Prednisolone may interact with:

• Non-steroidal anti-inflammatory drugs (NSAIDs)
• Certain antibiotics (e.g., rifampicin)
• Anticoagulants (may affect blood clotting)
• Diuretics (may increase potassium loss)

Always inform your healthcare provider about any medications or supplements you are taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture and direct sunlight
• Do not freeze liquid forms
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for the next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Severe swelling
• High blood sugar levels
• Mood changes or agitation
• Visual disturbances

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to prednisolone or related medications
• Active untreated infections
• Certain fungal infections

Brand Names / Alternatives

• Deltasone
• Prelone
• Orapred
• Hydrocortone (for some indications)
• Generic name: Prednisolone