Prednisone

Description

Prednisone is a corticosteroid medication used to treat a variety of conditions by reducing inflammation and suppressing the immune system. It is effective in managing symptoms associated with many disorders, including allergic reactions, autoimmune diseases, and specific types of cancer.

Uses / Indications

• Inflammatory conditions (e.g., arthritis, lupus)
• Severe allergic reactions
• Asthma exacerbations
• Adrenal insufficiency (Addison’s disease)
• Certain skin disorders (e.g., eczema, psoriasis)
• Cancer treatments (e.g., lymphomas, leukemias)

Dosage and Administration

Adults:
Dosage typically ranges from 5 mg to 60 mg daily, depending on the severity of the condition and the clinician’s recommendation.

Children:
Dosage is based on the child’s weight and the specific condition, and should be determined by a qualified healthcare provider.

Note: Dosage may vary based on individual medical conditions and responses to treatment.

How It Works (Mechanism of Action)

Prednisone works by mimicking the effects of cortisol, a natural hormone produced by the adrenal glands. It binds to glucocorticoid receptors, leading to decreased inflammation and immune responses, effectively managing symptoms related to many diseases and conditions.

Side Effects

Common side effects:

• Increased appetite
• Weight gain
• Difficulty sleeping (insomnia)
• Mood changes (anxiety, irritability)

Rare/serious side effects:

• Severe allergic reactions (rash, swelling, difficulty breathing)
• Increased blood sugar levels (risk of diabetes)
• Long-term use may lead to osteoporosis

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Tell your doctor if you have a history of infections, liver disease, or diabetes
• Use caution with live vaccines while taking prednisone
• Taper off gradually under medical supervision to avoid adrenal crisis

Drug Interactions

May interact with:

• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Anticoagulants (blood thinners)
• Diuretics (may increase the risk of low potassium)
• Certain vaccines (live vaccines may be less effective)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Extreme fatigue
• Elevated blood sugar levels
• Swelling in the extremities
• Mood swings

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to prednisone or other corticosteroids
• Systemic fungal infections
• Certain viral infections (e.g., herpes simplex of the eye)

Brand Names / Alternatives

• Deltasone
• Rayos
• Meticorten
• Prednicot
• Generic name: Prednisone