Cefadroxil

Description

Cefadroxil is a broad-spectrum antibiotic used to treat various bacterial infections. It belongs to the cephalosporin class of antibiotics and works by inhibiting the synthesis of the bacterial cell wall, ultimately leading to the death of the bacteria responsible for infections.

Uses / Indications

• Skin infections (e.g., cellulitis, abscess)
• Respiratory tract infections (e.g., pneumonia, bronchitis)
• Urinary tract infections
• Otitis media (ear infections)
• Bone infections (osteomyelitis)
• Throat infections (e.g., pharyngitis, tonsillitis) caused by susceptible bacteria

Dosage and Administration

Adults:
Typical dosage is 500 mg every 12 hours or 1 g once daily, depending on the severity of the infection.

Children:
30 mg/kg/day in divided doses (up to 1 g), usually given every 12 hours.

Note: Dosage may vary based on the type of infection and doctor’s advice.

How It Works (Mechanism of Action)

Cefadroxil works by binding to specific proteins located in the bacterial cell wall, blocking the cross-linking of peptidoglycan, which is essential for cell wall integrity. This action compromises the structural integrity of bacteria, leading to their lysis and death.

Side Effects

Common side effects:

• Nausea
• Diarrhea
• Abdominal pain
• Rash

Rare/serious side effects:

• Severe allergic reactions (rash, itching, swelling)
• Clostridium difficile-associated diarrhea
• Liver dysfunction (rare)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Inform your doctor if you have a history of allergies to cephalosporins or penicillin.
• Use with caution in patients with kidney impairment.
• Prolonged use may lead to superinfection; monitor for new symptoms.

Drug Interactions

May interact with:

• Probenecid (can increase cefadroxil levels)
• Anticoagulants (may enhance anticoagulant effects)
• Live bacterial vaccines (may be less effective)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (15°C–30°C / 59°F–86°F)
• Keep away from moisture, heat, and direct light
• Once reconstituted, refrigerate and use within 14 days
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Nausea and vomiting
• Diarrhea
• Severe allergic reactions

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to cefadroxil or other cephalosporins
• Severe allergic reactions to penicillin

Brand Names / Alternatives

• Duricef
• Generic name: Cefadroxil