Cefixime

Cefixime 100mg

Cefixime is a broad-spectrum antibiotic belonging to the cephalosporin class, used to treat a variety of bacterial infections, including infections of the ear, throat, and urinary tract. By inhibiting the formation of bacterial cell walls, it effectively stops the growth and multiplication of bacteria, helping to resolve infections. Cefixime is commonly prescribed for conditions such as gonorrhea and bronchitis, providing relief from symptoms while combating the underlying infection.

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Description

Cefixime is a broad-spectrum antibiotic belonging to the cephalosporin class, used to treat various bacterial infections. It is effective by interfering with the synthesis of the bacterial cell wall, ultimately leading to cell death and the elimination of the infection.

Uses / Indications

Acute otitis media (middle ear infections)
Pharyngitis and tonsillitis
Community-acquired pneumonia
Urinary tract infections (UTIs)
Gonorrhea (uncomplicated infections)
Skin and soft tissue infections

Dosage and Administration

Adults and children 12 years and older:
400 mg once daily or 200 mg twice daily for most infections.

Children aged 6 months to 12 years:
Dosage is based on body weight; typically 8 mg/kg/day in two divided doses, not exceeding 400 mg.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Cefixime works by inhibiting the bacterial cell wall synthesis through binding to penicillin-binding proteins. This disruption compromises the structural integrity of the bacteria, thereby causing cell lysis and death, effectively treating the infection.

Side Effects

Common side effects:

Diarrhea
Nausea or vomiting
Abdominal pain
Headache

Rare/serious side effects:

Allergic reactions (rash, itching, swelling)
Severe gastrointestinal effects (colitis)
Liver enzyme abnormalities

Seek medical attention if serious side effects occur.

Precautions / Warnings

Notify your doctor if you have a history of allergy to penicillins or cephalosporins
Use caution in patients with renal impairment
Monitor closely for antibiotic-associated colitis

Drug Interactions

May interact with:

Anticoagulants (may enhance their effects)
Probenecid (may increase cefixime levels)
Other antibiotics (risk of increased side effects)
Diuretics (especially aminoglycosides may increase nephrotoxicity)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

Store at room temperature (20°C–25°C / 68°F–77°F)
Protect from moisture and light
Liquid forms should be refrigerated and shaken well before use
Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

Severe gastrointestinal disturbances
Confusion or altered mental status
Severe allergic reactions (swelling, rash, and difficulty breathing)

Contact a poison control center or seek emergency medical help immediately.

Contraindications

Allergic to Cefixime or other cephalosporins
History of severe allergic reaction to any beta-lactam antibiotics

Brand Names / Alternatives

Suprax
Cefspan
Cefix
Generic name: Cefixime