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Cefpodoxime

Cefpodoxime 100mg, 200mg

Cefpodoxime is a broad-spectrum oral cephalosporin antibiotic used to treat various bacterial infections by inhibiting cell wall synthesis in bacteria. It is commonly prescribed for conditions such as pneumonia, bronchitis, and skin infections, as well as urinary tract infections. By targeting susceptible bacteria, Cefpodoxime helps alleviate symptoms and promote recovery while minimizing the risk of antibiotic resistance.

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Description

Cefpodoxime is a broad-spectrum cephalosporin antibiotic used to treat various bacterial infections. It works by inhibiting bacterial cell wall synthesis, leading to cell death and effectively eliminating the infection.

Uses / Indications

  • Upper respiratory tract infections, such as sinusitis and pharyngitis
  • Lower respiratory tract infections, including pneumonia
  • Skin and soft tissue infections
  • Urinary tract infections (UTIs)
  • Gonorrhea
  • Certain types of bacterial infections in adults and children

Dosage and Administration

Adults:
Recommended dosage is typically 200 mg to 400 mg every 12 hours, depending on the type and severity of the infection.

Children:
Dosing is based on the child’s weight, usually 10 mg/kg every 12 hours (not exceeding 400 mg per day).

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Cefpodoxime disrupts the synthesis of the bacterial cell wall by binding to penicillin-binding proteins, ultimately leading to bacterial cell lysis and death. Its broad-spectrum activity makes it effective against various Gram-positive and Gram-negative bacteria.

Side Effects

Common side effects:

  • Diarrhea
  • Nausea or vomiting
  • Stomach pain
  • Headache

Rare/serious side effects:

  • Severe allergic reactions (rash, itching, swelling)
  • Clostridium difficile-associated diarrhea (CDAD)
  • Liver dysfunction (rare)

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your healthcare provider if you have a history of allergies to cephalosporins or penicillins
  • Use cautiously in patients with kidney impairment
  • Monitor for signs of antibiotic-associated colitis, especially if diarrhea is present

Drug Interactions

May interact with:

  • Probenecid (may increase cefpodoxime levels)
  • Anticoagulants (may enhance blood-thinning effects)
  • Other antibiotics (potential competition for action)
  • Medications affecting kidney function

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct light
  • Refrigerate liquid formulations if necessary
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Nausea
  • Vomiting
  • Diarrhea
  • Severe stomach cramps

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergic to Cefpodoxime or any other cephalosporins
  • Severe allergic reactions to penicillin antibiotics

Brand Names / Alternatives

  • Vantin
  • Generics available under the name Cefpodoxime