Erythromycin

Erythromycin 250mg, 500mg

Erythromycin is an antibiotic used to treat various bacterial infections by inhibiting the growth of bacteria. It is effective against a range of infections, including respiratory tract infections, skin infections, and certain sexually transmitted diseases. Erythromycin works by interfering with the bacteria’s ability to produce proteins essential for their growth, thereby helping the body to eliminate the infection. It is commonly prescribed for patients who are allergic to penicillin or when penicillin is not suitable.

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Description

Erythromycin is a macrolide antibiotic used to treat various bacterial infections. It works by inhibiting bacterial protein synthesis, thereby stopping the growth of bacteria and helping to eliminate infections.

Uses / Indications

Bacterial respiratory tract infections (e.g., pneumonia, bronchitis)
Skin infections, including acne
Ocular infections caused by susceptible bacteria
Treatment of rheumatic fever in penicillin-allergic patients
Whooping cough (pertussis)
Certain gastrointestinal infections like gastric ulcers caused by Helicobacter pylori (in combination with other medications)

Dosage and Administration

Adults:
250 mg to 500 mg every 6 to 12 hours depending on the severity and type of infection.

Children:
Dosage is typically based on body weight; usually 30 mg/kg/day divided into multiple doses.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Erythromycin works by binding to the 50S ribosomal subunit of bacteria, preventing them from producing proteins essential for their growth and reproduction. This action effectively halts bacterial proliferation, allowing the immune system to clear the infection.

Side Effects

Common side effects:

Nausea
Vomiting
Diarrhea
Stomach cramps

Rare/serious side effects:

Severe allergic reactions (rash, itching, swelling)
Liver problems (symptoms may include jaundice)
Crazy or abnormal heart rhythms (QT prolongation)

Seek medical attention if serious side effects occur.

Precautions / Warnings

Tell your doctor if you have liver disease, heart problems, or a history of allergic reactions to antibiotics.
Use caution if combining with other medications that can affect heart rhythm.
Complete the full course of therapy to reduce the risk of antibiotic resistance.

Drug Interactions

Erythromycin may interact with:

Anticoagulants (e.g., warfarin)
Statins (risk of muscle damage)
Certain antifungal medications
Medications that affect liver enzymes

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

Store at room temperature (20°C–25°C / 68°F–77°F)
Keep away from moisture, heat, and direct light
Do not freeze liquid forms
Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

Severe gastrointestinal distress
Hearing loss
Rash
Severe diarrhea

Contact a poison control center or seek emergency medical help immediately.

Contraindications

Allergic to erythromycin or other macrolide antibiotics
History of cholestatic jaundice/hepatic dysfunction associated with prior use

Brand Names / Alternatives

Erythrocin
EES (Erythromycin Ethylsuccinate)
Ilotycin
Generic name: Erythromycin