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Ivermectin

Ivermectin 3mg, 6mg, 12mg

Ivermectin is an antiparasitic medication commonly used to treat various infections caused by parasites, including river blindness (onchocerciasis) and lymphatic filariasis. It works by targeting and disrupting the nervous system of the parasites, leading to their paralysis and death. Additionally, Ivermectin has been explored for potential uses in treating certain viral infections and skin conditions such as scabies. It is typically administered as a single oral dose and has a favorable safety profile when used as directed.

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Description

Ivermectin is a broad-spectrum antiparasitic medication primarily used to treat various types of parasitic infections. It works by inhibiting the growth and reproduction of parasites, disrupting their neuromuscular function and leading to their elimination from the body.

Uses / Indications

  • Onchocerciasis (river blindness)
  • Lymphatic filariasis (elephantiasis)
  • Strongyloidiasis (intestinal parasite infection)
  • Scabies (mites infestation)
  • Pediculosis (lice infestation)
  • Certain cases of cutaneous larva migrans

Dosage and Administration

Adults and children over 15 kg:
The dosage varies depending on the condition being treated. Typically, for onchocerciasis, a single oral dose of 150 mcg/kg is administered.

For children weighing less than 15 kg:
Dosage will be calculated based on weight and must be determined by a healthcare provider.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Ivermectin targets specific chloride channels found in parasites, leading to paralysis and death of the parasites. By binding to glutamate-gated chloride channels and other targets, it also disrupts the neurotransmission necessary for the survival of parasitic organisms.

Side Effects

Common side effects:

  • Nausea
  • Dizziness
  • Diarrhea
  • Fatigue

Rare/serious side effects:

  • Severe allergic reactions (rash, swelling, difficulty breathing)
  • Neurological effects (such as confusion or seizures)
  • Hepatitis or liver injury (very rare)

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Tell your doctor if you have liver disease, are pregnant, or breastfeeding.
  • Use caution if you have a history of neurological disorders.
  • Not suitable for use in certain parasitic infections without medical evaluation.

Drug Interactions

May interact with:

  • Other medications that affect liver enzymes
  • Drugs that may cause drowsiness
  • Certain anticonvulsants

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Nausea and vomiting
  • Dizziness
  • Severe fatigue
  • Confusion or disorientation

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergy to Ivermectin or any of its components
  • Severe liver disease

Brand Names / Alternatives

  • Stromectol
  • Ivomec (vet use)
  • Other generics available