Norfloxacin

Norfloxacin 400mg

Norfloxacin is a broad-spectrum antibiotic that belongs to the fluoroquinolone class, used primarily to treat bacterial infections, particularly those affecting the urinary tract and gastrointestinal system. By inhibiting bacterial DNA synthesis, it effectively targets a wide range of Gram-negative and some Gram-positive bacteria. Commonly prescribed for conditions such as urinary tract infections and traveler’s diarrhea, Norfloxacin helps in controlling infection and alleviating symptoms associated with these illnesses.

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Description

Norfloxacin is a fluoroquinolone antibiotic used to treat bacterial infections in the urinary tract and other parts of the body. It works by inhibiting bacterial DNA synthesis, ultimately leading to the death of susceptible bacteria.

Uses / Indications

Uncomplicated urinary tract infections (UTIs)
Chronic bacterial prostatitis
Bacterial infections of the gastrointestinal tract
Prevention of urinary tract infections in patients undergoing certain surgical procedures
Treatment of certain types of bacterial infections as determined by a healthcare provider

Dosage and Administration

Adults:
400 mg orally every 12 hours for 3 days for UTIs. The dosage may vary based on the severity of the infection and physician recommendation.

Renal impairment:
Adjustments may be needed depending on the level of renal function; consult with a healthcare professional for specific recommendations.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Norfloxacin acts by inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential enzymes for bacterial DNA replication and transcription. This mechanism makes it effective against a broad spectrum of gram-negative and some gram-positive bacteria.

Side Effects

Common side effects:

Nausea and vomiting
Diarrhea
Abdominal pain
Headache

Rare/serious side effects:

Tendon damage or rupture
Severe allergic reactions (rash, difficulty breathing)
Lightheadedness or fainting
Changes in mood or behavior

Seek medical attention if serious side effects occur.

Precautions / Warnings

Tell your doctor if you have a history of tendon issues, epilepsy, liver or kidney disease, or if you are pregnant/breastfeeding
Use caution if combining with other medications, particularly those that may affect heart rhythm
Avoid excessive sun exposure; Norfloxacin can increase sensitivity to sunlight

Drug Interactions

May interact with:

Antacids containing aluminum, magnesium, or calcium (may reduce efficacy of Norfloxacin)
Warfarin and other anticoagulants (may increase bleeding risk)
Certain antiarrhythmic medications
Certain medications that affect kidney function

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

Store at room temperature (20°C–25°C / 68°F–77°F)
Keep away from moisture, heat, and direct light
Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

Severe dizziness
Confusion or agitation
Prolonged QT interval (may cause heart rhythm problems)

Contact a poison control center or seek emergency medical help immediately.

Contraindications

Allergic to Norfloxacin or other fluoroquinolone antibiotics
Pregnant women (unless prescribed by a healthcare professional)
Children and adolescents under 18 years of age (unless carefully indicated due to specific infections)

Brand Names / Alternatives

Noroxin
Generic name: Norfloxacin