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Ofloxacin

Ofloxacin 200mg, 400mg

Ofloxacin is a fluoroquinolone antibiotic used to treat various bacterial infections by inhibiting the bacteria’s ability to replicate and repair their DNA. It is commonly prescribed for infections of the respiratory tract, urinary tract, skin, and certain types of gastroenteritis. Ofloxacin is effective against both gram-negative and some gram-positive bacteria, making it a versatile option in the management of acute bacterial conditions.

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Description

Ofloxacin is a fluoroquinolone antibiotic used to treat a variety of bacterial infections. It works by stopping the growth of bacteria, making it effective against certain types of infections in different parts of the body.

Uses / Indications

  • Urinary tract infections (UTIs)
  • Respiratory tract infections
  • Skin and soft tissue infections
  • Ocular infections (eye drops form)
  • Infections caused by susceptible strains of bacteria

Dosage and Administration

Adults:
Typically, 200 mg to 400 mg once daily, depending on the specific infection being treated. Always follow your healthcare provider’s instructions.

Children:
Dosage is determined by a healthcare professional based on body weight and the type of infection.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for DNA replication and repair, ultimately leading to bacterial cell death. This makes it effective against a broad spectrum of bacterial infections.

Side Effects

Common side effects:

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness

Rare/serious side effects:

  • Tendon rupture or pain
  • Severe allergic reactions (rash, swelling, difficulty breathing)
  • Changes in mood or mental state

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor if you have a history of tendon problems or seizures
  • Use caution if combining with other medications that may affect heart rhythm
  • Not recommended for use during pregnancy or breastfeeding unless advised by a healthcare provider

Drug Interactions

May interact with:

  • Antacids (may reduce effectiveness)
  • Other antibiotics
  • Medications that affect heart rhythm
  • Corticosteroids (increased risk of tendon damage)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (15°C–30°C / 59°F–86°F)
  • Keep away from moisture, heat, and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Nausea
  • Dizziness
  • Tremors
  • Confusion

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergic to Ofloxacin or other fluoroquinolones
  • History of tendon disorders related to fluoroquinolone use

Brand Names / Alternatives

  • Floxin
  • Ocuflox (ophthalmic solution)
  • Generic name: Ofloxacin