Roxithromycin

Description

Roxithromycin is a macrolide antibiotic that is effective in treating various bacterial infections. It works by inhibiting bacterial protein synthesis, thus stopping the growth and reproduction of bacteria. Roxithromycin is particularly noted for its ability to combat infections in the respiratory tract and skin.

Uses / Indications

• Respiratory tract infections (e.g., bronchitis, pneumonia)
• Skin infections (e.g., impetigo, cellulitis)
• Ear infections (otitis media)
• Throat infections (pharyngitis, tonsillitis)
• Acne vulgaris (as part of comprehensive treatment)
• Certain sexually transmitted infections (e.g., chlamydia)

Dosage and Administration

Adults:
150 mg once daily or 300 mg in divided doses (typically 150 mg twice a day) as prescribed by a healthcare provider.

Children:
Dosage is typically based on the child’s weight and specific condition; refer to a pediatrician for appropriate recommendations.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Roxithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible bacteria, thereby disrupting their function and preventing them from producing vital proteins necessary for their growth and survival.

Side Effects

Common side effects:

• Nausea
• Diarrhea
• Stomach pain
• Headache
• Dizziness

Rare/serious side effects:

• Severe allergic reactions (rash, itching, swelling)
• Liver dysfunction (abdominal pain, dark urine, jaundice)
• Prolonged QT interval (irregular heartbeats)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Inform your doctor if you have liver disease, kidney problems, or a history of arrhythmias.
• Use caution if you’re pregnant or breastfeeding; consult your doctor.
• May reduce the effectiveness of certain vaccines; inform your healthcare provider before immunizations.

Drug Interactions

May interact with:

• Anticoagulants (e.g., warfarin)
• Other antibiotics (risk of increased side effects)
• Medications that affect liver enzymes
  (may alter Roxithromycin levels).

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Severe gastrointestinal symptoms (nausea, vomiting, diarrhea)
• Rapid or irregular heartbeat
• Dizziness or fainting

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to Roxithromycin or any components of the formulation
• Previous serious reaction to macrolide antibiotics

Brand Names / Alternatives

• Rulide
• Roxithromycin (generic name)
• Various other brand names depending on the region