Tinidazole

Description

Tinidazole is an antimicrobial medication belonging to the nitroimidazole class, primarily used to treat various infections caused by anaerobic bacteria and certain parasites. It works by inhibiting nucleic acid synthesis, effectively killing sensitive organisms and aiding in the resolution of infections.

Uses / Indications

• Bacterial vaginosis
• Trichomoniasis (a sexually transmitted infection)
• Amebiasis (intestinal infection caused by Entamoeba histolytica)
• Giardiasis (intestinal infection caused by Giardia lamblia)
• Post-operative infections
• In combination with other medications to treat Helicobacter pylori infection

Dosage and Administration

Adults:
2 grams orally as a single dose for Trichomoniasis or 1 gram once daily for 5 days for Bacterial Vaginosis.

Pediatric patients (age 3 and older):
Dosage is typically based on body weight and specific infection; consult a pediatrician for the exact recommendation.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Tinidazole works by disrupting the DNA and nucleic acid synthesis of susceptible organisms, rendering them inactive and ultimately leading to their destruction. Its specific action against anaerobic bacteria and certain parasites helps to effectively clear infections.

Side Effects

Common side effects:

• Nausea or vomiting
• Metallic taste in the mouth
• Stomach pain or discomfort
• Headache

Rare/serious side effects:

• Severe allergic reactions (rash, itching, swelling)
• Neurological effects (seizures, dizziness, numbness)
• Stomatitis (inflammation of the mouth)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Inform your doctor if you have a history of blood disorders, liver disease, or are pregnant/breastfeeding.
• Use caution if combining with alcohol, as it can cause adverse reactions such as flushing, nausea, and vomiting.
• May affect laboratory tests, including those for liver function.

Drug Interactions

May interact with:

• Alcohol (can increase the risk of severe side effects)
• Other medications that affect the liver
• Anticoagulants (blood thinners), such as warfarin

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Nausea or vomiting
• Dizziness or confusion
• Severe headache
• Seizures

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergies to Tinidazole or other nitroimidazole derivatives
• History of blood disorders or central nervous system diseases

Brand Names / Alternatives

• Tindamax
• Generic name: Tinidazole