Aripiprazole

Aripiprazole 2mg, 5mg, 10mg, 15mg, 20mg, 30mg.
Aripiprazole is an atypical antipsychotic medication used to treat a variety of mental health conditions, including schizophrenia, bipolar disorder, and major depressive disorder as an adjunct therapy. It works by modulating the activity of neurotransmitters in the brain, particularly dopamine and serotonin, which helps to stabilize mood and reduce symptoms such as hallucinations, delusions, and mood swings. Aripiprazole is often favored for its lower risk of sedation and weight gain compared to other antipsychotic medications.
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Aripiprazole is an atypical antipsychotic medication used to treat various mental health conditions. It works by modulating the activity of certain neurotransmitters in the brain, notably dopamine and serotonin, helping to balance mood and behavior.
Uses / Indications
- Schizophrenia
- Bipolar disorder (manic or mixed episodes)
- Major depressive disorder (as an adjunctive treatment)
- Irritability associated with autistic disorder
- Tourette’s disorder
- Psychotic disorders in children and adolescents
Dosage and Administration
Adults:
Start with 10-15 mg once daily, with a maximum dose of 30 mg per day based on clinical response and tolerability.
Children aged 6 years and older:
Initial dosage typically ranges from 2 mg to 10 mg once daily, adjusted based on the specific condition and response.
Note: Dosage may vary based on individual medical conditions or doctor’s recommendations.
How It Works (Mechanism of Action)
Aripiprazole works primarily as a dopamine D2 receptor partial agonist and serotonin 5-HT1A receptor agonist, while also antagonizing 5-HT2A receptors. This unique action helps stabilize mood and manage symptoms of psychosis without the same risk of sedation or weight gain that other antipsychotics may cause.
Side Effects
Common side effects:
- Nausea
- Vomiting
- Dizziness
- Anxiety
- Insomnia
Rare/serious side effects:
- Severe allergic reactions (rash, itching, swelling)
- Neuroleptic Malignant Syndrome (NMS)
- Tardive dyskinesia (involuntary movements)
- Suicidal thoughts or behavior
Seek medical attention immediately if serious side effects occur.
Precautions / Warnings
- Inform your doctor if you have a history of seizures, cardiovascular issues, or diabetes
- Caution is advised when using in combination with other medications that affect the central nervous system
- Monitor for any worsening of mood or suicidal thoughts, especially during dosage adjustments
Drug Interactions
May interact with:
- Antidepressants (SSRIs and SNRIs)
- Other antipsychotics
- Certain antihypertensive medications
- Medications that inhibit CYP3A4 enzymes
Always inform your healthcare provider about any other medications or supplements you’re taking.
Storage Instructions
- Store at room temperature (20°C–25°C / 68°F–77°F)
- Keep away from moisture, heat, and direct light
- Keep out of reach of children
Missed Dose / Overdose
Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up on doses.
Overdose symptoms:
- Severe drowsiness
- Unusual movements
- Difficulty breathing
- Rapid heartbeat
Contact a poison control center or seek emergency medical help immediately.
Contraindications
- Allergic to aripiprazole or any of its components
- History of a serious reaction to antipsychotic medications
Brand Names / Alternatives
- Abilify
- Abilify MyCite (smart pill offering digital tracking)
- Generic name: Aripiprazole