Desvenlafaxine

Description

Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) prescribed for the treatment of major depressive disorder (MDD) in adults. It works by inhibiting the reabsorption of serotonin and norepinephrine in the brain, which helps to improve mood and alleviate symptoms of depression.

Uses / Indications

• Major depressive disorder (MDD)
• Generalized anxiety disorder (GAD)
• Management of symptoms associated with menopause (hot flashes)
• Chronic pain disorders related to depression
• Potential use in anxiety-related disorders

Dosage and Administration

Adults:
The recommended starting dose is 50 mg once daily, taken with or without food. Dose adjustments may be made based on individual patient response.

Older adults or patients with renal impairment:
Starting at a lower dose (e.g., 25 mg) may be considered to reduce the risk of side effects.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Desvenlafaxine selectively inhibits the reuptake of serotonin and norepinephrine by blocking their transport proteins, which increases the levels of these neurotransmitters in the brain. This balanced increase in serotonin and norepinephrine is thought to help regulate mood and emotional state.

Side Effects

Common side effects:

• Nausea
• Dizziness
• Dry mouth
• Fatigue
• Increased sweating

Rare/serious side effects:

• Elevated blood pressure
• Severe allergic reactions (rash, swelling, difficulty breathing)
• Serotonin syndrome (symptoms include agitation, hallucinations, and increased heart rate)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Inform your doctor if you have a history of high blood pressure, liver disease, or a seizure disorder.
• Use caution if combining with other medications that affect serotonin levels.
• Discontinuation should be gradual, as abrupt withdrawal may lead to withdrawal symptoms.

Drug Interactions

May interact with:

• Monoamine oxidase inhibitors (MAOIs)
• Other antidepressants (SSRIs, SNRIs)
• Anticoagulants (may increase bleeding risk)
• Certain medications that affect liver enzymes

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Drowsiness or extreme fatigue
• Increased heart rate
• Severe nausea or vomiting
• Seizures (rare)

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to Desvenlafaxine or related SNRIs
• Current or recent use of MAOIs

Brand Names / Alternatives

• Pristiq
• Khedezla
• Generic name: Desvenlafaxine