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Paroxetine

Paroxetine 10mg, 20mg, 30mg, 40mg

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) commonly prescribed to treat depression, anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder. By increasing serotonin levels in the brain, it helps improve mood and emotional balance. Paroxetine is often favored for its efficacy in reducing anxiety and improving overall mental health, but it may have side effects such as nausea, dizziness, and sexual dysfunction.

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Description

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant commonly used to treat various mental health conditions. By increasing the levels of serotonin, a natural substance in the brain, Paroxetine helps improve mood, alleviate anxiety, and promote emotional stability.

Uses / Indications

  • Major depressive disorder
  • Generalized anxiety disorder
  • Obsessive-compulsive disorder (OCD)
  • Panic disorder
  • Social anxiety disorder
  • Post-traumatic stress disorder (PTSD)

Dosage and Administration

Adults:
The typical starting dose is 20 mg once daily, which may be adjusted by your doctor based on your response to treatment.

Older adults:
A lower starting dose may be recommended (usually 10 mg daily) to minimize side effects.

Note: Always follow your physician’s instructions regarding dosage and any adjustments.

How It Works (Mechanism of Action)

Paroxetine functions by selectively inhibiting the reuptake of serotonin in the brain, increasing its availability in the synaptic cleft. This action helps to enhance mood and reduce anxiety, making it effective for various psychological conditions.

Side Effects

Common side effects:

  • Nausea
  • Dry mouth
  • Drowsiness or fatigue
  • Insomnia
  • Sweating

Rare/serious side effects:

  • Suicidal thoughts or behavior
  • Serotonin syndrome (high fever, muscle spasms, confusion)
  • Allergic reactions (rash, itching, swelling)

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor if you have a history of seizures, liver disease, or bipolar disorder.
  • Monitor closely when discontinuing or adjusting the dose as withdrawal symptoms may occur.
  • Avoid alcohol while taking Paroxetine due to the risk of enhanced side effects.

Drug Interactions

May interact with:

  • Monoamine oxidase inhibitors (MAOIs)
  • Other antidepressants
  • Blood thinners (warfarin)
  • St. John’s wort

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Protect from moisture, heat, and direct sunlight
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Drowsiness
  • Nausea or vomiting
  • Rapid heartbeat
  • Unusual agitation or nervousness

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergic to Paroxetine or any of its components
  • Concurrent use with MAO inhibitors

Brand Names / Alternatives

  • Paxil
  • Paxil CR (controlled release)
  • Brisdelle (for menopause-related symptoms)
  • Generic name: Paroxetine