Griseofulvin

Description

Griseofulvin is an antifungal medication primarily used to treat dermatophyte infections, which affect the skin, hair, and nails. It works by inhibiting fungal cell reproduction, ultimately leading to the death of the fungus and clearing up the infection.

Uses / Indications

• Tinea capitis (scalp ringworm)
• Tinea corporis (body ringworm)
• Tinea pedis (athlete’s foot)
• Tinea cruris (jock itch)
• Onychomycosis (fungal nail infections)
• Generalized dermatophyte infections

Dosage and Administration

Adults:
The recommended dose is typically 500 mg once daily or 250 mg twice daily, taken with food for better absorption.

Children:
The dosage varies based on body weight; it is generally calculated at 10-20 mg/kg of body weight, administered once daily.

Note: Dosage may be adjusted based on the severity of the infection or doctor’s recommendation.

How It Works (Mechanism of Action)

Griseofulvin is incorporated into the fungal cell wall, disrupting the mitotic spindle during cell division. This action prevents the fungi from reproducing and allows the body’s immune system to clear the infection.

Side Effects

Common side effects:

• Nausea or vomiting
• Diarrhea
• Fatigue
• Headache

Rare/serious side effects:

• Liver problems (indicated by yellowing of the skin or eyes)
• Severe allergic reactions (rash, itching, swelling)
• Stevens-Johnson syndrome (serious skin reaction)

Seek medical attention if severe side effects occur.

Precautions / Warnings

• Inform your doctor if you have liver disease, porphyria, or are pregnant/breastfeeding.
• Monitor for any unusual changes in mood or behavior.
• Use caution when operating machinery or driving until you know how Griseofulvin affects you.

Drug Interactions

May interact with:

• Oral contraceptives (may reduce their effectiveness)
• Warfarin (increased risk of bleeding)
• Alcohol (may increase the risk of liver side effects)
• Certain antibiotics (may alter effectiveness)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (15°C–30°C / 59°F–86°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Nausea
• Severe headache
• Dizziness
• Confusion or disorientation

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to Griseofulvin or any of its components
• Porphyria
• Severe liver disease

Brand Names / Alternatives

• Gris-PEG
• Grifulvin V
• Generic name: Griseofulvin