Terbinafine

Description

Terbinafine is an antifungal medication primarily used to treat fungal infections of the skin and nails. It works by inhibiting the growth of fungi, effectively treating conditions like athlete’s foot, ringworm, and onychomycosis (fungal nail infections).

Uses / Indications

• Athlete’s foot (tinea pedis)
• Ringworm (tinea corporis)
• Jock itch (tinea cruris)
• Fungal nail infections (onychomycosis)
• Fungal skin infections

Dosage and Administration

Adults:
For skin infections, a typical dosage is 250 mg once daily for 2 to 4 weeks. For nail infections, it may be prescribed for 6 to 12 weeks.

Children:
Dosing for children varies based on weight and condition; consult a healthcare provider for specific recommendations.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Terbinafine works by inhibiting the enzyme squalene epoxidase, disrupting the synthesis of ergosterol, an essential component of fungal cell membranes. This results in cell death and helps clear up the infection.

Side Effects

Common side effects:

• Gastrointestinal upset (nausea, diarrhea)
• Headache
• Skin rash
• Taste disturbances

Rare/serious side effects:

• Liver problems (symptoms include jaundice, dark urine)
• Severe allergic reactions (rash, swelling, difficulty breathing)
• Blood disorders (unusual bruising or bleeding)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Tell your doctor if you have liver disease, a history of renal problems, or if you are pregnant/breastfeeding.
• Use caution in patients with a history of alcohol abuse or severe skin reactions.
• Regular monitoring may be necessary for long-term use.

Drug Interactions

May interact with:

• Anticoagulants (may increase bleeding risk)
• Certain antifungal medications (like itraconazole)
• CYP450 enzyme inhibitors (may affect terbinafine metabolism)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Nausea or vomiting
• Headache
• Dizziness
• Liver-related symptoms (jaundice or dark urine)

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to Terbinafine or any component of the formulation
• Severe liver disease
• Current or past history of lupus erythematosus

Brand Names / Alternatives

• Lamisil
• Terbinafine Hydrochloride
• Generic name: Terbinafine