Albendazole

Albendazole 400mg

Albendazole is an anthelmintic medication primarily used to treat a variety of parasitic infections, including those caused by roundworms, tapeworms, and flukes. It works by inhibiting the production of microtubules in the parasites, ultimately leading to their death. Commonly prescribed for conditions like neurocysticercosis, hydatid disease, and other helminthic infections, Albendazole is effective in managing both intestinal and tissue-based infestations.

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Description

Albendazole is a broad-spectrum anthelmintic medication used to treat a variety of parasitic worm infestations. It works by inhibiting the growth and reproduction of parasites, effectively eliminating them from the body.

Uses / Indications

Neurocysticercosis (pork tapeworm infection)
Hydatid disease (echinococcal infection)
Ascariasis (roundworm infection)
Enterobiasis (pinworm infection)
Trichuriasis (whipworm infection)
Hookworm infections

Dosage and Administration

Adults and children 2 years and older:
The dosage varies depending on the specific infection. Generally, 400 mg single dose for most conditions. Neurocysticercosis may require 400 mg twice daily for a duration recommended by a healthcare provider.

Children under 2 years:
Dosage should be determined by a physician based on the child’s weight and medical condition.

Note: Always follow your doctor’s recommendations for dosage and duration of treatment.

How It Works (Mechanism of Action)

Albendazole works by inhibiting the polymerization of tubulin into microtubules, which is necessary for cell division and function in parasites. This disruption halts their metabolism and reproduction, leading to their death.

Side Effects

Common side effects:

Nausea
Vomiting
Abdominal pain
Dizziness

Rare/serious side effects:

Liver toxicity (elevated enzymes)
Severe allergic reactions (rash, swelling, trouble breathing)
Aplastic anemia (very rare)

If you experience serious side effects, seek medical attention promptly.

Precautions / Warnings

Inform your doctor of any liver disorders or pre-existing blood disorders before taking Albendazole.
Pregnant or breastfeeding women should consult a healthcare provider, as Albendazole may affect fetal development.
Routine liver function tests may be advised during prolonged therapy.

Drug Interactions

Albendazole may interact with:

Cimetidine (may increase albendazole levels)
Medications affecting liver enzymes
Drugs that may cause bone marrow suppression

Always inform your healthcare provider about any medications or supplements you are currently taking.

Storage Instructions

Store at room temperature (15°C–30°C / 59°F–86°F)
Keep away from moisture and direct sunlight
Ensure the medication is kept out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s close to the time for your next dose, skip the missed one. Do not take two doses at once.

Overdose symptoms:

Severe gastrointestinal distress
Drowsiness or confusion
Unusual bruising or bleeding

Contact poison control or seek emergency medical assistance immediately if an overdose is suspected.

Contraindications

Known hypersensitivity to Albendazole or related compounds
Severe liver disease

Brand Names / Alternatives

Albenza
Generics available
Alternative medications may include Mebendazole, Ivermectin for different infections