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Buspirone

Buspirone 5mg, 10mg, 15mg, 30mg

Buspirone is an anxiolytic medication primarily used to treat generalized anxiety disorder (GAD). It works by affecting certain neurotransmitters in the brain, particularly serotonin and dopamine, to help alleviate anxiety symptoms without the sedative effects associated with other anxiolytics. Buspirone is typically taken on a regular basis and is known for its lower risk of dependence, making it a suitable option for long-term anxiety management.

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Description

Buspirone is an anxiolytic medication primarily used for the treatment of anxiety disorders. It acts on the brain’s serotonin and dopamine receptors, helping to alleviate symptoms of anxiety without the sedative effects commonly associated with other anti-anxiety medications.

Uses / Indications

  • Generalized Anxiety Disorder (GAD)
  • Short-term management of anxiety symptoms
  • Adjunct treatment for anxiety in patients with depression
  • Management of anxiety caused by medical conditions

Dosage and Administration

Adults:
Initial dose of 10 mg, taken two to three times daily. The dosage may be increased gradually based on patient’s response, with a maximum recommended dose of 60 mg per day.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Buspirone functions primarily as a serotonin 5-HT1A receptor agonist and acts as a weak antagonist at dopamine D2 receptors. This unique mechanism helps to reduce anxiety signals in the brain, making it effective for managing anxiety without causing sedation.

Side Effects

Common side effects:

  • Dizziness
  • Nausea
  • Headache
  • Nervousness
  • Lightheadedness

Rare/serious side effects:

  • Fast or irregular heartbeat
  • Severe allergic reactions (rash, itching, swelling)
  • Severe abdominal pain

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor if you have a history of liver or kidney issues
  • Use caution if combining with other medications that affect serotonin levels
  • Not recommended for use in patients with a known hypersensitivity to Buspirone

Drug Interactions

May interact with:

  • Monoamine oxidase inhibitors (MAOIs)
  • Antidepressants (SSRIs or SNRIs)
  • Other medications that affect serotonin levels
  • CYP3A4 inhibitors (may increase buspirone levels)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Severe drowsiness
  • Confusion
  • Nausea or vomiting
  • Fast or irregular heartbeat

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergic to Buspirone or any of its ingredients
  • Acute or severe drug toxicity

Brand Names / Alternatives

  • Buspar
  • BuSpar Dividose
  • Generic name: Buspirone