Fluvoxamine

Description

Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) commonly prescribed for the treatment of obsessive-compulsive disorder (OCD) and social anxiety disorder. It functions by increasing the levels of serotonin, a neurotransmitter that helps regulate mood, in the brain.

Uses / Indications

• Obsessive-compulsive disorder (OCD)
• Social anxiety disorder (social phobia)
• Panic disorder
• Depression, as part of a comprehensive treatment plan
• Prevention of relapse in patients with recurrent major depressive disorder

Dosage and Administration

Adults:
Initial dose is typically 50 mg once daily (may be adjusted based on response and tolerance). Maximum recommended dose is 300 mg per day.

Children aged 8-17 years:
Initial dose usually starts at 25 mg once daily, which may be gradually increased based on clinical response.

Note: Dosage may vary based on specific medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Fluvoxamine works by selectively inhibiting the reuptake of serotonin in the brain, which increases serotonin levels in the synaptic cleft and helps alleviate symptoms of anxiety and obsessive-compulsive behaviors. Its efficacy in balancing serotonin neurotransmission contributes to mood stabilization and anxiety reduction.

Side Effects

Common side effects:

• Nausea
• Drowsiness or fatigue
• Dry mouth
• Insomnia
• Loss of appetite

Rare/serious side effects:

• Suicidal thoughts or behaviors
• Severe allergic reactions (rash, itching, swelling)
• Serotonin syndrome (symptoms may include agitation, confusion, rapid heart rate)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Discuss your medical history with your doctor, especially if you have a history of liver disease, seizures, or mood disorders.
• Use caution if combining with other medications that have sedative effects.
• May increase the risk of bleeding; inform your doctor if you’re taking anticoagulants.

Drug Interactions

May interact with:

• Monoamine oxidase inhibitors (MAOIs)
• Other SSRIs or other antidepressants
• Certain antipsychotics
• Medications that influence liver enzymes (e.g., some antifungals and antibiotics)

Always inform your healthcare provider about any other medications or supplements you are taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Severe drowsiness
• Rapid heartbeat
• Nausea or vomiting
• Confusion or agitation

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to Fluvoxamine or any of its ingredients
• Use of MAOIs within 14 days

Brand Names / Alternatives

• Luvox
• Luvox CR
• Generic name: Fluvoxamine