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Celecoxib

Celecoxib 100mg, 200mg

Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that is primarily used to relieve pain and inflammation associated with conditions such as arthritis, menstrual pain, and acute pain. By selectively inhibiting the cyclooxygenase-2 (COX-2) enzyme, Celecoxib helps reduce the production of prostaglandins, which are substances in the body that mediate pain and inflammation. This medication offers an effective option for managing pain while minimizing the gastrointestinal side effects often associated with traditional NSAIDs.

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Description

Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) primarily used to relieve pain and inflammation. It selectively inhibits cyclooxygenase-2 (COX-2), an enzyme involved in the production of inflammatory substances, providing effective relief for conditions associated with pain.

Uses / Indications

  • Osteoarthritis
  • Rheumatoid arthritis
  • Acute pain management
  • Dysmenorrhea (period pain)
  • Familial adenomatous polyposis (FAP) prevention

Dosage and Administration

Adults:
The recommended dose for osteoarthritis and rheumatoid arthritis is usually 200 mg daily, divided into 2 doses. For acute pain, the dose may begin with 400 mg, followed by 200 mg if needed on the first day, and then 200 mg once daily as necessary.

Note: Dosage may vary based on individual medical conditions or doctor’s guidance.

How It Works (Mechanism of Action)

Celecoxib selectively inhibits the COX-2 enzyme, which reduces the production of prostaglandins that cause pain and inflammation. By targeting this specific enzyme, Celecoxib provides anti-inflammatory effects while sparing COX-1, which is associated with protecting the stomach lining.

Side Effects

Common side effects:

  • Abdominal pain
  • Nausea
  • Diarrhea
  • Headache

Rare/serious side effects:

  • Increased risk of cardiovascular events (e.g., heart attack, stroke)
  • Gastrointestinal bleeding
  • Severe allergic reactions (rash, swelling, difficulty breathing)

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor if you have a history of heart disease, high blood pressure, liver or kidney issues, or gastrointestinal problems
  • Use with caution in elderly patients, as the risk of cardiovascular events may be higher
  • Not recommended during the third trimester of pregnancy

Drug Interactions

May interact with:

  • Anticoagulants (e.g., warfarin, increasing bleeding risk)
  • Other NSAIDs or aspirin
  • Certain antihypertensive medications (may reduce effectiveness)
  • Selective serotonin reuptake inhibitors (SSRIs)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Severe abdominal pain
  • Nausea and vomiting
  • Dizziness or headaches
  • Shortness of breath

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergic to Celecoxib or any of its ingredients
  • History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
  • Severe heart failure

Brand Names / Alternatives

  • Celebrex
  • Generic name: Celecoxib