Etodolac

Description

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) used primarily to relieve pain, reduce inflammation, and decrease fever. It works by inhibiting certain substances in the body that cause inflammation and pain, making it an effective treatment option for various conditions.

Uses / Indications

• Osteoarthritis
• Rheumatoid arthritis
• Acute pain management
• Chronic pain conditions
• Post-operative pain relief
• Menstrual cramps

Dosage and Administration

Adults:
The recommended initial dose is typically 300 mg to 400 mg taken two to three times a day, not exceeding 1,000 mg per day. Always follow your doctor’s specific instructions regarding dosage.

Note: Dosage may vary based on individual medical conditions or physician recommendations.

How It Works (Mechanism of Action)

Etodolac inhibits the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which play a key role in the synthesis of prostaglandins; compounds that mediate inflammation, pain, and fever. By reducing prostaglandin levels, Etodolac effectively decreases pain and inflammation.

Side Effects

Common side effects:

• Nausea
• Dizziness
• Stomach pain or discomfort
• Headache

Rare/serious side effects:

• Severe gastrointestinal bleeding
• Liver problems (yellowing of the skin or eyes)
• Heart attack or stroke risk
• Allergic reactions (rash, itchiness, swelling)

If any serious side effects occur, seek medical attention immediately.

Precautions / Warnings

• Inform your doctor if you have a history of heart disease, high blood pressure, or gastrointestinal issues.
• Caution is advised if you are pregnant, planning to become pregnant, or breastfeeding.
• Avoid use in conjunction with alcohol, which can increase the risk of stomach bleeding.

Drug Interactions

Etodolac may interact with:

• Other NSAIDs
• Anticoagulants (blood thinners)
• Diuretics (water pills)
• Certain antidepressants

Always inform your healthcare provider about any other medications or supplements you are taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture and direct sunlight
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up on doses.

Overdose symptoms:

• Severe drowsiness
• Nausea or vomiting
• Stomach pain
• Difficulty breathing

Contact a poison control center or seek emergency medical help immediately if an overdose is suspected.

Contraindications

• Allergic to Etodolac or any ingredients in the formulation
• Severe allergic reactions to other NSAIDs

Brand Names / Alternatives

• Lodine
• Etogesic
• Generic name: Etodolac