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Etoricoxib

Etoricoxib 30mg, 60mg, 90mg, 120mg

Etoricoxib is a selective COX-2 inhibitor nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, and acute pain. By targeting the COX-2 enzyme, it helps reduce the production of prostaglandins that cause pain and swelling, providing effective relief for patients while minimizing gastrointestinal side effects commonly associated with traditional NSAIDs.

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Description

Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) that is primarily used for the management of pain and inflammation in various conditions. It works by selectively inhibiting the enzyme COX-2, which plays a significant role in the production of prostaglandins—substances that mediate inflammation and pain in the body.

Uses / Indications

  • Osteoarthritis
  • Rheumatoid arthritis
  • Acute gouty arthritis
  • Chronic musculoskeletal pain
  • Management of pain following surgery (post-operative pain)
  • Pain associated with dental procedures

Dosage and Administration

Adults:
Typically, the recommended dose is 60 mg once daily for osteoarthritis, 90 mg once daily for rheumatoid arthritis, and 120 mg for acute gouty arthritis. Dosage may vary depending on the condition and individual response.

Note: Always follow your doctor’s instructions regarding dosage, as it may vary based on your specific medical condition.

How It Works (Mechanism of Action)

Etoricoxib selectively inhibits COX-2 enzymes, thereby reducing the synthesis of prostaglandins, which are responsible for causing inflammation and pain. This selective action helps minimize gastrointestinal side effects associated with non-selective NSAIDs.

Side Effects

Common side effects:

  • Nausea
  • Headache
  • Dizziness
  • Abdominal pain

Rare/serious side effects:

  • Increased risk of cardiovascular events (heart attack, stroke)
  • Kidney problems (decreased urine output, swelling)
  • Severe allergic reactions (rash, swelling, difficulty breathing)

If you experience any serious side effects, seek medical attention immediately.

Precautions / Warnings

  • Inform your doctor if you have a history of heart disease, stroke, liver, or kidney issues.
  • Caution is advised when combining Etoricoxib with other medications that affect heart health.
  • Use during pregnancy should be discussed with your healthcare provider.

Drug Interactions

Etoricoxib may interact with:

  • Anticoagulants (e.g., warfarin; increased bleeding risk)
  • Other NSAIDs or steroids (increased risk of gastrointestinal issues)
  • Diuretics (reduced effectiveness of diuretics)
  • Certain antihypertensive medications (possible decreased efficacy)

Always inform your healthcare provider about all medications and supplements you are taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Severe dizziness
  • Nausea or vomiting
  • Unusual tiredness or weakness
  • Difficulty breathing

Contact a poison control center or seek emergency medical help immediately if an overdose is suspected.

Contraindications

  • Allergic to Etoricoxib or any of its components
  • Severe renal impairment
  • Active peptic ulcer disease
  • History of gastrointestinal bleeding

Brand Names / Alternatives

  • Arcoxia
  • Generic name: Etoricoxib