Indomethacin

Description

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) primarily used to relieve pain, inflammation, and fever. It works by inhibiting the production of prostaglandins, which are chemicals in the body responsible for pain and inflammation.

Uses / Indications

• Osteoarthritis
• Rheumatoid arthritis
• Gouty arthritis (gout)
• Shoulder pain and bursitis
• Mild to moderate pain relief
• Fever reduction

Dosage and Administration

Adults:
Initial dose typically ranges from 20 mg to 40 mg taken two to three times a day, depending on the condition being treated.

Children:
Dosage is usually based on weight and specific medical conditions; consult a pediatrician for appropriate dosing.

Note: Dosage may vary based on individual needs and doctor’s advice.

How It Works (Mechanism of Action)

Indomethacin works by blocking the action of cyclooxygenase (COX), an enzyme involved in the production of prostaglandins. By reducing prostaglandin levels, Indomethacin helps alleviate pain and inflammation associated with various conditions.

Side Effects

Common side effects:

• Gastrointestinal discomfort (nausea, indigestion)
• Headache
• Dizziness
• Rash

Rare/serious side effects:

• Ulceration or bleeding in the gastrointestinal tract
• Severe allergic reactions (rash, itching, swelling)
• Kidney issues (reduced urine output, swelling)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Inform your doctor if you have a history of heart disease, liver disease, or gastrointestinal issues.
• Use caution if pregnant, planning to become pregnant, or breastfeeding.
• May increase the risk of cardiovascular events; consult your healthcare provider.

Drug Interactions

May interact with:

• Other NSAIDs (increased risk of side effects)
• Aspirin (may reduce its effect)
• Anticoagulants (may increase bleeding risk)
• Diuretics and certain hypertension medications (impact on kidney function)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember, unless it’s almost time for your next dose. Do not double up.

Overdose symptoms:

• Gastrointestinal bleeding (black or bloody stools)
• Severe nausea or vomiting
• Dizziness or fainting
• Severe headache

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to Indomethacin or other NSAIDs
• History of severe gastrointestinal or bleeding disorders
• Active peptic ulcer disease

Brand Names / Alternatives

• Indocin
• Indomethacin SR (sustained release)
• Generic name: Indomethacin