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Piroxicam

Piroxicam 20mg, 40mg

Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and stiffness associated with conditions such as arthritis and musculoskeletal disorders. By inhibiting the enzymes responsible for producing prostaglandins, substances that mediate inflammation and pain in the body, Piroxicam effectively reduces discomfort and enhances mobility for those suffering from chronic pain. It is often prescribed for long-term management of inflammatory conditions.

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Description

Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, reduce inflammation, and decrease fever. It works by inhibiting enzymes in the body known as cyclooxygenases (COX-1 and COX-2), which play a crucial role in the production of prostaglandins—substances that mediate inflammation and pain responses.

Uses / Indications

  • Osteoarthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Acute pain or flare-ups of chronic pain conditions
  • Pain relief following surgery or injury

Dosage and Administration

Adults:
Typical starting dose is 20 mg, taken once daily. If necessary, it may be increased to 40 mg per day, divided into two doses.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Piroxicam works by non-selectively inhibiting the activity of cyclooxygenase (COX-1 and COX-2) enzymes, leading to a decrease in the synthesis of prostaglandins. This results in reduced inflammation, pain, and fever, making it effective for various inflammatory and painful conditions.

Side Effects

Common side effects:

  • Stomach upset or pain
  • Dizziness or headache
  • Nausea or vomiting
  • Diarrhea or constipation

Rare/serious side effects:

  • Severe allergic reactions (rash, itching, breathing difficulties)
  • Heart attack or stroke (especially with prolonged use)
  • Gastrointestinal bleeding or ulcers

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor if you have a history of heart disease, gastrointestinal issues, or are pregnant/breastfeeding
  • Use with caution in the elderly, as they may be more susceptible to side effects
  • Long-term use may increase the risk of serious cardiovascular events and gastrointestinal bleeding

Drug Interactions

May interact with:

  • Other NSAIDs or aspirin (increased risk of gastrointestinal bleeding)
  • Anticoagulants (blood thinners, may enhance bleeding risk)
  • Certain antihypertensive medications (may reduce effectiveness)
  • Lithium (may increase levels in the blood)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (15°C–30°C / 59°F–86°F)
  • Keep away from moisture, heat, and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Nausea and vomiting
  • Stomach pain; gastrointestinal bleeding
  • Dizziness or fainting
  • Unusual tiredness or respiratory issues

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergic to Piroxicam or other NSAIDs
  • History of severe gastrointestinal bleeding or ulcers

Brand Names / Alternatives

  • Feldene
  • Piroxicam toothpaste
  • Various generic formulations