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Montelukast

Montelukast 10mg, 5mg

Montelukast is a leukotriene receptor antagonist used to prevent and manage asthma symptoms and alleviate seasonal allergic rhinitis (hay fever). By blocking the action of leukotrienes, substances in the body that cause inflammation and constriction of the airways, it helps improve lung function and reduce the frequency of asthma attacks. Montelukast is often prescribed for both children and adults to enhance breathing comfort and overall respiratory health.

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Description

Montelukast is a prescription medication that belongs to a class of drugs known as leukotriene receptor antagonists. It is primarily used to manage and prevent symptoms of asthma and seasonal allergies by blocking the action of leukotrienes, which are substances in the body that can cause airway constriction and inflammation.

Uses / Indications

  • Asthma management (chronic treatment)
  • Prevention of exercise-induced bronchoconstriction
  • Seasonal allergic rhinitis (hay fever)
  • Perennial allergic rhinitis
  • Nasal congestion, runny nose, sneezing, and itchy eyes associated with allergies

Dosage and Administration

Adults and children 15 years and older:
10 mg once daily, taken in the evening.

Children aged 6–14 years:
5 mg once daily, taken in the evening (typically 1 chewable tablet or 1 packet of granules).

Children aged 2–5 years:
4 mg once daily, taken in the evening (usually 1 chewable tablet or 1 packet of granules).

Note: Dosage may vary based on individual medical conditions or doctor’s recommendations.

How It Works (Mechanism of Action)

Montelukast selectively blocks the action of leukotrienes by binding to their receptors, thereby reducing inflammation, bronchoconstriction, and mucus secretion in the airways. This helps to alleviate the symptoms of asthma and allergic rhinitis.

Side Effects

Common side effects:

  • Headache
  • Nausea
  • Diarrhea
  • Fatigue
  • Dizziness

Rare/serious side effects:

  • Changes in mood or behavior (e.g., agitation, aggression, anxiety)
  • Severe allergic reactions (e.g., rash, swelling, difficulty breathing)
  • Suicidal thoughts or actions (very rare)

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Consult your doctor if you have liver disease, phenylketonuria (PKU), or are pregnant/breastfeeding
  • Do not discontinue treatment of asthma medications without consulting your healthcare provider
  • May not be suitable for individuals with a history of psychiatric disorders

Drug Interactions

Montelukast may interact with:

  • Rifampin (may decrease montelukast effectiveness)
  • Some medications affecting liver enzymes
  • Other medications prescribed for asthma (e.g., corticosteroids)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct light
  • Keep both chewable tablets and granules in their original container to protect from light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Drowsiness
  • Thirst
  • Abdominal pain
  • Nausea

Contact a poison control center or seek emergency medical help immediately if overdose is suspected.

Contraindications

  • Allergic to Montelukast or any of its components
  • Previous severe reactions to leukotriene modifiers

Brand Names / Alternatives

  • Singulair
  • Generic name: Montelukast