Desogestrel

Description

Desogestrel is a synthetic progestin used primarily in hormonal contraceptives. It is designed to prevent pregnancy by inhibiting ovulation, thickening the cervical mucus, and altering the uterine lining to prevent implantation. This medication is often combined with estrogen in combination oral contraceptives.

Uses / Indications

• Contraception (prevention of pregnancy)
• Regulation of menstrual cycles
• Management of endometriosis
• Treatment of menstrual disorders
• Reduction of menstrual-related symptoms

Dosage and Administration

Adults:
Typically, Desogestrel is taken as a single 75 mcg tablet once daily, beginning at least 7 days before engaging in sexual intercourse for optimal contraceptive effect.

For individuals switching from another contraceptive:
Follow your healthcare provider’s instructions on how to transition, which may involve taking the first dose of Desogestrel on the same day as the last dose of the previous contraceptive.

Note: Dosage may vary depending on medical advice and specific health needs.

How It Works (Mechanism of Action)

Desogestrel primarily prevents pregnancy by acting as a progestin, which inhibits the release of luteinizing hormone (LH) necessary for ovulation. Additionally, it thickens the cervical mucus, making it more challenging for sperm to enter the uterus, and alters the endometrium, reducing the likelihood of implantation.

Side Effects

Common side effects:

• Nausea
• Breast tenderness
• Headache
• Mood changes
• Irregular menstrual bleeding

Rare/serious side effects:

• Blood clots (in legs, lungs, or eyes)
• Severe allergic reactions (rash, itching, swelling)
• Liver problems (yellowing of the skin or eyes)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Inform your doctor if you have a history of blood clots, liver disease, or are pregnant/breastfeeding
• May not be suitable for smokers over 35 years of age
• Regular medical check-ups are advised while using hormonal contraceptives

Drug Interactions

Desogestrel may interact with:

• Certain antibiotics (may decrease contraceptive effectiveness)
• Anticonvulsants (may also decrease effectiveness)
• Herbal supplements (e.g., St. John’s Wort)
• HIV medications

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember, even if it’s the next day. If it is nearly time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Nausea and vomiting
• Dizziness
• Breast tenderness or unusual vaginal bleeding

Contact a poison control center or seek emergency medical help immediately if you suspect an overdose.

Contraindications

• Allergic to Desogestrel or any component of the formulation
• History of thrombosis or certain cancers (e.g., breast or estrogen-sensitive cancers)

Brand Names / Alternatives

• Cerazette
• Marvelon
• Mercilon
• Cilest
• Generic name: Desogestrel