Drospirenone

Description

Drospirenone is a synthetic progestin that is commonly used in combination with estrogen in hormonal contraceptives. It functions by mimicking the effects of natural progesterone to regulate various processes in the body, including the menstrual cycle and prevention of ovulation.

Uses / Indications

• Hormonal contraception (birth control pill)
• Management of premenstrual dysphoric disorder (PMDD)
• Treatment of moderate acne in women of at least 14 years of age who desire an oral contraceptive for birth control
• Management of symptoms associated with menopause in hormone replacement therapy
• Regulation of abnormal uterine bleeding

Dosage and Administration

Adults:
For most indications, a typical initial dosage is 3 mg taken orally once daily. The dosage may vary based on the specific condition being treated and the healthcare provider’s recommendation.

Note: Dosage may differ based on individual medical conditions and should be taken as directed by a healthcare professional.

How It Works (Mechanism of Action)

Drospirenone works by inhibiting ovulation, thickening cervical mucus to prevent sperm from reaching the egg, and altering the uterine lining to prevent implantation. Its unique formulation has a mild anti-androgenic effect, which can help reduce symptoms associated with conditions such as acne and PMDD.

Side Effects

Common side effects:

• Nausea
• Headaches
• Breast tenderness
• Mood changes
• Weight gain

Rare/serious side effects:

• Blood clots (deep vein thrombosis or pulmonary embolism)
• Strokes or heart attacks
• Severe allergic reactions (hives, difficulty breathing)
• High potassium levels (hyperkalemia)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Inform your doctor if you have a history of blood clots, liver disease, or uncontrolled hypertension
• Use caution if you smoke, especially if over age 35, as this increases the risk of serious cardiovascular events
• Regular check-ups are recommended to monitor your health, especially when first starting treatment

Drug Interactions

Drospirenone may interact with:

• Antibiotics (may reduce effectiveness of the contraceptive)
• Anticonvulsants (may reduce hormonal effectiveness)
• Certain antifungals and herbal supplements, such as St. John’s Wort
• Medications affecting potassium levels or renal function

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Severe nausea and vomiting
• Vaginal bleeding
• Dizziness or fainting

Contact a poison control center or seek emergency medical help immediately if an overdose is suspected.

Contraindications

• Allergic to Drospirenone or any ingredients in the formulation
• History of blood clots or certain types of cancers (hormone-sensitive cancers)

Brand Names / Alternatives

• Yaz
• Yasmin
• Ocella
• Genora 0.3/0.03
• Generic name: Drospirenone