Clopidogrel

Clopidogrel 75mg

Clopidogrel is an antiplatelet medication used to reduce the risk of heart attack and stroke by preventing blood clots. It works by inhibiting platelet aggregation, which is the clumping together of platelets in the blood. Commonly prescribed for individuals with a history of cardiovascular conditions, including those who have undergone stent placement or bypass surgery, Clopidogrel helps improve blood flow and reduce the likelihood of serious cardiovascular events.

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Description

Clopidogrel is an antiplatelet medication that reduces the risk of strokes, heart attacks, and other cardiovascular events by preventing blood cells (platelets) from aggregating and forming clots. It is often prescribed to patients who have experienced a recent heart attack or stroke, as well as to those with certain types of heart disease.

Uses / Indications

Prevention of atherothrombotic events in patients with a history of myocardial infarction (heart attack)
Prevention of strokes in patients with a history of transient ischemic attacks (TIAs)
Management of patients with unstable angina and non-ST elevation myocardial infarction
Post-operative management in patients who have undergone coronary artery stenting
Prevention of cardiovascular events in patients with established peripheral arterial disease

Dosage and Administration

Adults:
The typical starting dose for Clopidogrel is 75 mg once daily. In some cases, a loading dose of 300 mg may be administered once prior to starting the maintenance dose.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Clopidogrel is a prodrug that is metabolized into its active form, which selectively inhibits the P2Y12 ADP receptor on platelets, reducing platelet activation and aggregation. This action helps to prevent the formation of harmful blood clots.

Side Effects

Common side effects:

Bleeding (including easy bruising and prolonged bleeding from cuts)
Gastrointestinal upset (nausea, diarrhea)
Headache
Fatigue

Rare/serious side effects:

Severe bleeding (such as gastrointestinal bleeding or intracranial hemorrhage)
Thrombotic thrombocytopenic purpura (TTP)
Allergic reactions (rash, itching, swelling)

Seek medical attention if serious side effects occur.

Precautions / Warnings

Tell your doctor if you have a history of bleeding disorders, liver disease, or are pregnant/breastfeeding
Use caution when combining with other medications that increase bleeding risk
Regular monitoring may be needed if you have certain medical conditions or are taking certain medications

Drug Interactions

May interact with:

Warfarin (anticoagulants)
Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs)
Certain blood pressure medications
Proton pump inhibitors (such as omeprazole) can reduce the effectiveness of Clopidogrel

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

Store at room temperature (20°C–25°C / 68°F–77°F)
Keep away from moisture, heat, and direct light
Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

Increased bleeding or bruising
Severe gastrointestinal symptoms
Dizziness or fainting

Contact a poison control center or seek emergency medical help immediately.

Contraindications

Active bleeding (such as peptic ulcer or hemorrhagic stroke)
Hypersensitivity to Clopidogrel or any ingredient in the formulation

Brand Names / Alternatives

Plavix
Generic name: Clopidogrel