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Dipyridamole

Dipyridamole 75mg, 100mg

Dipyridamole is an antiplatelet medication that works by preventing blood clots from forming in the blood vessels. It is commonly used in combination with other medications to reduce the risk of stroke and heart attack in patients with certain heart conditions. By inhibiting the activity of platelets, Dipyridamole helps improve blood flow and reduce the chances of clot-related complications, making it an important option for those at risk of cardiovascular events.

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Description

Dipyridamole is an antiplatelet medication that helps prevent blood clots by inhibiting platelet aggregation. It is often used as an adjunct treatment in patients who have undergone certain types of heart surgery or those with a history of blood clots, contributing to better blood flow and cardiovascular health.

Uses / Indications

  • Prevention of thromboembolic events in patients with artificial heart valves
  • Reducing the risk of stroke in patients with prior transient ischemic attack (TIA) or ischemic stroke
  • Used in combination with other medications, such as aspirin, for enhanced antiplatelet effect
  • Diagnostic agent in certain types of stress tests (nuclear imaging)
  • Management of certain conditions associated with ischemia

Dosage and Administration

Adults:
Typically, the initial dose for adults is 75 to 100 mg orally, taken two to three times daily, depending on the specific condition being treated.

Note: Dosage may be adjusted based on individual health needs and doctor’s advice.

How It Works (Mechanism of Action)

Dipyridamole works by inhibiting the uptake of adenosine, leading to increased blood concentration of adenosine, which in turn inhibits platelet activation and aggregation. Additionally, it causes vasodilation in certain blood vessels, enhancing blood flow effectively.

Side Effects

Common side effects:

  • Headache
  • Dizziness or lightheadedness
  • Nausea
  • Abdominal pain

Rare/serious side effects:

  • Low blood pressure
  • Unusual bleeding or bruising
  • Severe allergic reactions (rash, itching, swelling)

Seek immediate medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor if you have liver disease, heart problems, or are pregnant/breastfeeding
  • Use with caution if you have a history of gastrointestinal bleeding or recently undergone surgery
  • Regular monitoring may be required during treatment

Drug Interactions

Dipyridamole may interact with:

  • Anticoagulants (may increase bleeding risk)
  • Certain medications affecting blood pressure
  • Caffeine (may decrease the effectiveness of the medication)
  • Other antiplatelet or anticoagulant medications

Always inform your healthcare provider of all medications and supplements you are taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Severe headache
  • Extreme dizziness or fainting
  • Unusual or excessive bleeding
  • Rapid heartbeat

Contact a poison control center or seek emergency medical help immediately if an overdose is suspected.

Contraindications

  • Allergic to Dipyridamole or any of its components
  • Severe hypotension (low blood pressure)

Brand Names / Alternatives

  • Persantine
  • Generic name: Dipyridamole