Felodipine

Description

Felodipine is a long-acting calcium channel blocker primarily used to manage high blood pressure (hypertension). It works by relaxing the blood vessels, allowing blood to flow more easily and reducing the workload on the heart.

Uses / Indications

• Hypertension (high blood pressure)
• Angina pectoris (chest pain due to reduced blood flow to the heart)
• Prevention of cardiovascular events in high-risk patients

Dosage and Administration

Adults:
Typically, 5 mg to 10 mg once daily, depending on blood pressure levels and response.

Note: Dosage may vary based on individual medical conditions or doctor’s advice.

How It Works (Mechanism of Action)

Felodipine selectively inhibits calcium channels in vascular smooth muscle, leading to vasodilation (widening of blood vessels). This decreases peripheral vascular resistance and lowers blood pressure without significantly affecting heart rate.

Side Effects

Common side effects:

• Swelling of the legs and ankles (peripheral edema)
• Flushing
• Headache
• Dizziness

Rare/serious side effects:

• Rapid or irregular heartbeat
• Severe allergic reactions (rash, itching, swelling)
• Low blood pressure/dizziness upon standing (orthostatic hypotension)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Notify your doctor if you have a history of heart disease, liver issues, or are pregnant/breastfeeding.
• Use caution if combining with other medications that lower blood pressure.
• Regular monitoring of blood pressure is recommended while on this medication.

Drug Interactions

May interact with:

• Other antihypertensive medications (may enhance blood pressure-lowering effect)
• Grapefruit juice (may increase blood levels of Felodipine)
• Certain antifungal medications
• Medications that affect liver enzymes

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Severe dizziness or fainting
• Rapid heartbeat
• Nausea or vomiting
• Flushing

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to Felodipine or any of its components
• Severe hypotension (low blood pressure)
• Severe aortic stenosis

Brand Names / Alternatives

• Plendil
• Felodipine extended-release (generic)