Terazosin

Description

Terazosin is an alpha-1 adrenergic blocker primarily used in the treatment of benign prostatic hyperplasia (BPH) and hypertension. By relaxing muscles in the prostate and bladder neck, it enhances urine flow in men with BPH and helps lower blood pressure.

Uses / Indications

• Benign prostatic hyperplasia (BPH)
• Hypertension (high blood pressure)
• Management of urinary retention due to BPH
• Improvement of urinary flow rate
• Reduction of symptoms associated with BPH, such as difficulty in urination

Dosage and Administration

For adults with hypertension or BPH:
Initial dosage is typically 1 mg once daily at bedtime, which may be adjusted as needed up to a maximum of 10 mg once daily.

Note: Dosage may vary based on medical condition and doctor’s recommendations.

How It Works (Mechanism of Action)

Terazosin works by selectively blocking alpha-1 adrenergic receptors, which results in relaxation of smooth muscle in the prostate and blood vessels. This action helps to reduce blood pressure and alleviate urinary symptoms associated with BPH.

Side Effects

Common side effects:

• Dizziness or lightheadedness
• Fatigue
• Nausea
• Headache

Rare/serious side effects:

• Severe allergic reactions (rash, itching, swelling)
• Fainting or severe dizziness upon standing (orthostatic hypotension)
• Priapism (prolonged erection)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Inform your doctor if you have kidney or liver issues, or if you are pregnant or breastfeeding
• Use caution when combining with other medications that lower blood pressure
• May cause dizziness; avoid driving or operating heavy machinery until you know how it affects you

Drug Interactions

Terazosin may interact with:

• Other antihypertensive medications
• PDE5 inhibitors (like sildenafil or tadalafil)
• Certain diuretics
• Alcohol (may enhance blood pressure-lowering effects)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Severe dizziness
• Fainting
• Increased heart rate
• Nausea or vomiting

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to Terazosin or other alpha-1 blockers
• History of orthostatic hypotension or severe liver disease

Brand Names / Alternatives

• Hytrin
• Terazosin generic
• Various combination products available