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Torsemide

Torsemide 10mg, 20mg, 100mg

Torsemide is a loop diuretic medication primarily used to treat conditions such as edema associated with heart failure, liver cirrhosis, and renal disease, as well as hypertension. By promoting the excretion of excess fluid and sodium through urine, it helps to reduce swelling and lower blood pressure. Torsemide is often favored for its efficacy and longer duration of action compared to other diuretics, providing symptom relief for patients dealing with fluid retention.

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Description

Torsemide is a potent loop diuretic (water pill) that is primarily used to treat fluid retention (edema) associated with conditions like heart failure, liver disease, and kidney disorders. It works by inhibiting the reabsorption of sodium and chloride in the kidneys, leading to increased urine production and helping to reduce excess fluid in the body.

Uses / Indications

  • Congestive heart failure
  • Edema associated with chronic kidney disease
  • Liver cirrhosis with fluid retention
  • Hypertension (high blood pressure) as part of a comprehensive treatment plan

Dosage and Administration

Adults:
Initial dose typically ranges from 10 mg to 20 mg once daily, with adjustment based on response.

Patients with renal impairment:
Lower doses may be required based on individual renal function.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Torsemide inhibits the Na-K-2Cl co-transporter in the ascending loop of Henle in the kidneys. This action prevents sodium and chloride reabsorption, promoting diuresis (increased urine output) and helping to eliminate excess fluid from the body.

Side Effects

Common side effects:

  • Increased urination
  • Dizziness or lightheadedness
  • Headache
  • Nausea

Rare/serious side effects:

  • Electrolyte imbalances (low potassium or sodium levels)
  • Severe dehydration
  • Allergic reactions (rash, itching, swelling)

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor if you have kidney disease, liver disease, or are pregnant/breastfeeding.
  • Use caution if you are taking medications that can affect electrolyte levels.
  • Regular blood tests may be required to monitor kidney function and electrolyte levels.

Drug Interactions

May interact with:

  • Other diuretics
  • Lithium (may increase lithium levels)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Medications affecting renal function or electrolyte balance

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Severe dehydration
  • Low blood pressure (fainting)
  • Rapid heartbeat
  • Confusion or disorientation

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergic to Torsemide or sulfonamide derivatives
  • Anuria (absence of urine output)

Brand Names / Alternatives

  • Demadex
  • Generic name: Torsemide