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Atorvastatin

Atorvastatin 10mg, 20mg, 40mg, 80mg

Atorvastatin is a cholesterol-lowering medication that belongs to a class of drugs known as statins. It works by inhibiting an enzyme involved in the production of cholesterol in the liver, thereby helping to decrease levels of LDL (bad cholesterol) and triglycerides while increasing HDL (good cholesterol). Atorvastatin is commonly prescribed to reduce the risk of heart disease, heart attacks, and strokes in individuals with high cholesterol or other cardiovascular risk factors.

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Description

Atorvastatin is a medication belonging to the statin class, primarily used to lower cholesterol levels and reduce the risk of cardiovascular diseases. It works by inhibiting an enzyme in the liver responsible for producing cholesterol, contributing to overall heart health and reducing the risk of heart attack and stroke.

Uses / Indications

  • Hyperlipidemia (high cholesterol)
  • Prevention of cardiovascular disease in at-risk populations
  • Familial hypercholesterolemia
  • Reduction of LDL (low-density lipoprotein) cholesterol
  • Increase in HDL (high-density lipoprotein) cholesterol levels
  • Lowering triglyceride levels

Dosage and Administration

Adults:
Initial dose typically 10 mg to 20 mg once daily, with a maximum dose of 80 mg as per physician’s recommendations.

Note: Dosage may vary based on individual medical conditions and doctor’s advice.

How It Works (Mechanism of Action)

Atorvastatin works by inhibiting the HMG-CoA reductase enzyme, which plays a crucial role in the biosynthesis of cholesterol in the liver. By reducing the production of cholesterol, atorvastatin lowers LDL cholesterol levels and triglycerides in the blood while slightly increasing HDL cholesterol levels.

Side Effects

Common side effects:

  • Muscle pain or weakness
  • Elevated liver enzymes (monitored with blood tests)
  • Digestive issues (nausea, diarrhea)
  • Headaches

Rare/serious side effects:

  • Rhabdomyolysis (severe muscle breakdown)
  • Allergic reactions (rash, itching, swelling)
  • Liver problems (yellowing of skin or eyes)

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor about any history of liver disease, muscle disorders, or are pregnant/breastfeeding
  • Caution advised when taking other cholesterol-lowering medications
  • Regular monitoring of lipid levels and liver function tests may be required

Drug Interactions

Atorvastatin may interact with:

  • Certain antibiotics and antifungals
  • Other cholesterol-lowering agents (especially fibrates)
  • CYP3A4 inhibitors (such as certain HIV medications)
  • Grapefruit juice (may increase atorvastatin levels)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Severe muscle pain
  • Nausea or vomiting
  • Fatigue
  • Weakness

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergy to atorvastatin or any components of the formulation
  • Active liver disease
  • Pregnancy and breastfeeding

Brand Names / Alternatives

  • Lipitor
  • Generic name: Atorvastatin