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Ezetimibe

Ezetimibe 10mg, 20mg

Ezetimibe is a lipid-lowering medication that works by reducing the absorption of cholesterol from the intestines, thereby lowering LDL (bad cholesterol) levels in the blood. It is often prescribed for patients with hyperlipidemia or those at risk of cardiovascular disease. Ezetimibe can be used alone or in combination with statins to enhance cholesterol-lowering effects, helping to improve overall heart health and reduce the risk of heart attacks and strokes.

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Description

Ezetimibe is a cholesterol-lowering medication that works by reducing the amount of cholesterol absorbed by the body from the diet. It is used to help lower levels of total cholesterol and LDL (low-density lipoprotein) cholesterol, commonly referred to as “bad” cholesterol, thereby reducing the risk of heart disease.

Uses / Indications

  • Primary hyperlipidemia (high cholesterol)
  • Sitosterolemia (a rare cholesterol absorption disorder)
  • Used in combination with statins for additional cholesterol reduction
  • Helps reduce the risk of heart attack and stroke
  • Management of patients with dyslipidemia

Dosage and Administration

Adults:
10 mg once daily, with or without food.

Note: Dosage may differ based on individual response or doctor’s recommendations.

How It Works (Mechanism of Action)

Ezetimibe selectively inhibits the absorption of cholesterol at the brush border of the small intestine, leading to decreased levels of cholesterol in the bloodstream. By targeting this absorption process, it effectively lowers total cholesterol and LDL cholesterol levels without affecting the levels of high-density lipoprotein (HDL) or triglycerides significantly.

Side Effects

Common side effects:

  • Abdominal pain
  • Diarrhea
  • Fatigue
  • Headache

Rare/serious side effects:

  • Liver enzyme abnormalities
  • Muscle pain or weakness (may indicate myopathy or rhabdomyolysis)
  • Allergic reactions (rash, swelling, difficulty breathing)

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor if you have liver disease, muscle problems, or are pregnant/breastfeeding
  • Use caution when taking with other cholesterol-lowering medications, especially statins
  • Regular monitoring of liver function and lipid levels may be needed during treatment

Drug Interactions

Ezetimibe may interact with:

  • Statins (may increase the risk of muscle injury)
  • Bile acid sequestrants (may reduce the effectiveness of Ezetimibe)
  • Anticoagulants (may enhance effects)
  • Other medications that affect cholesterol levels

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Severe dizziness
  • Confusion
  • Nausea
  • Liver-related symptoms (yellowing of skin/eyes)

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergy to Ezetimibe or any component of the formulation
  • Active liver disease or unexplained persistent elevations of liver enzymes

Brand Names / Alternatives

  • Zetia
  • Ezetrol (international)
  • Generic name: Ezetimibe