Fenofibrate

Fenofibrate 48mg, 145mg

Fenofibrate is a medication primarily used to lower cholesterol levels and triglycerides in the blood, helping to reduce the risk of cardiovascular diseases. It works by increasing the breakdown of fats in the body, thus improving lipid profiles, especially in individuals with hyperlipidemia or dyslipidemia. Often prescribed alongside a healthy diet and exercise, fenofibrate is beneficial for patients at risk of heart disease and related complications.

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Description

Fenofibrate is a medication used primarily to manage cholesterol levels in individuals at risk for cardiovascular disease. It works by activating peroxisome proliferator-activated receptor alpha (PPARα), which helps to reduce triglyceride levels and increase high-density lipoprotein (HDL) cholesterol, often referred to as the “good” cholesterol.

Uses / Indications

Hyperlipidemia (high cholesterol and triglycerides)
Dyslipidemia
To reduce the risk of cardiovascular events in patients with coronary artery disease
Combined with dietary changes to improve lipid profiles

Dosage and Administration

Adults:
The typical dosage is 48 mg to 145 mg once daily, taken with food (specific dose may vary depending on individual cholesterol levels and doctor’s advice).

Note: Dosage may be adjusted based on individual response and medical condition.

How It Works (Mechanism of Action)

Fenofibrate works by activating PPARα, which leads to increased oxidation of fatty acids and reduces the production of triglycerides in the liver. This action not only helps lower triglyceride levels but also promotes an increase in HDL cholesterol levels, contributing to overall cardiovascular health.

Side Effects

Common side effects:

Abdominal pain
Nausea
Back pain
Headache

Rare/serious side effects:

Muscle pain or weakness (rhabdomyolysis)
Liver dysfunction (indicated by jaundice or elevated liver enzymes)
Severe allergic reactions (rash, swelling, dizziness)

Contact a healthcare professional immediately if serious side effects occur.

Precautions / Warnings

Inform your doctor if you have liver or kidney problems, or have a history of gallbladder disease.
Use cautiously if you are pregnant or breastfeeding.
Regular lipid level monitoring is important during treatment.

Drug Interactions

May interact with:

Statins (increased risk of muscle injury)
Anticoagulants (may enhance their effects)
Other cholesterol-lowering medications
Certain diuretics or medications affecting the liver

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

Store at room temperature (20°C–25°C / 68°F–77°F)
Keep away from moisture, heat, and direct light
Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose. Do not double up.

Overdose symptoms:

Severe abdominal pain
Severe muscle weakness or pain
Nausea or vomiting

Seek emergency medical help immediately if an overdose is suspected.

Contraindications

Allergy to Fenofibrate or any components of the formulation
Severe liver or kidney disorders
Gallbladder disease

Brand Names / Alternatives

Tricor
Lofibra
Fenoglide
Antara
Generic name: Fenofibrate