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Gemfibrozil

Gemfibrozil 600mg

Gemfibrozil is a medication primarily used to lower high levels of triglycerides and cholesterol in the blood, particularly in individuals at risk for cardiovascular disease. It works by inhibiting the production of triglycerides in the liver and increasing the breakdown of fats. Gemfibrozil is often prescribed for patients with conditions such as hyperlipidemia or mixed dyslipidemia, helping to reduce the risk of heart attack and stroke by improving lipid profiles.

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Description

Gemfibrozil is a medication primarily used to lower triglyceride levels and improve cholesterol levels in the blood. It belongs to the class of drugs known as fibrates and works by reducing the production of triglycerides in the liver, thereby helping to prevent cardiovascular diseases.

Uses / Indications

  • Type IIb hyperlipidemia (elevated cholesterol and triglycerides)
  • Severe hypertriglyceridemia (triglycerides over 500 mg/dL)
  • Reduction of the risk of pancreatitis in patients with very high triglyceride levels
  • Improvement of lipid profiles in patients with coronary artery disease

Dosage and Administration

Adults:
600 mg taken twice daily, 30 minutes before breakfast and dinner.

Note: Dosage may vary based on individual patient characteristics and doctor’s advice.

How It Works (Mechanism of Action)

Gemfibrozil works by activating peroxisome proliferator-activated receptor alpha (PPAR-alpha), leading to increased oxidation of fatty acids and a decrease in triglyceride production by the liver. This results in lower triglyceride levels and an increase in high-density lipoprotein (HDL or “good” cholesterol) levels.

Side Effects

Common side effects:

  • Nausea or upset stomach
  • Diarrhea
  • Abdominal pain
  • Fatigue

Rare/serious side effects:

  • Muscle pain or weakness (myopathy)
  • Liver function abnormalities (elevated liver enzymes)
  • Gallstones

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Tell your doctor if you have liver disease, kidney problems, or a history of gallstones.
  • Use caution when combining with statins or other cholesterol-lowering medications due to the increased risk of muscle-related side effects.
  • Regular monitoring of liver function and lipid levels is recommended.

Drug Interactions

Gemfibrozil may interact with:

  • Statins (increased risk of muscle disorders)
  • Warfarin (may enhance anticoagulant effect)
  • Certain diabetes medications
  • Other medications that affect liver enzymes

Always inform your healthcare provider about any other medications or supplements you are taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s close to the time of your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Severe muscle pain or weakness
  • Nausea or vomiting
  • Fatigue

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergic to Gemfibrozil or any of its inactive ingredients
  • Severe liver or kidney impairment
  • Gallbladder disease

Brand Names / Alternatives

  • Lopid
  • Generic name: Gemfibrozil