Rosuvastatin

Description

Rosuvastatin is a widely prescribed medication belonging to the class of drugs known as statins. It is primarily used to lower cholesterol levels in the blood, helping to reduce the risk of heart disease and related complications. Rosuvastatin works by inhibiting HMG-CoA reductase, an enzyme involved in the body’s cholesterol production.

Uses / Indications

• Hyperlipidemia (high cholesterol)
• Prevention of atherosclerotic cardiovascular disease
• Familial hypercholesterolemia
• Treatment of conditions associated with high triglyceride levels
• Reducing the risk of heart attack and strokes in patients with known coronary artery disease

Dosage and Administration

Adults:
Start with a dose of 10 mg to 20 mg once daily, depending on the patient’s cholesterol levels and doctor’s recommendation. Dosage may be adjusted based on treatment response.

Children aged 10 years and older:
Typically, 5 mg to 20 mg once daily if indicated for familial hypercholesterolemia.

Note: Dosage may vary based on individual circumstances, and it’s essential to follow your doctor’s instructions.

How It Works (Mechanism of Action)

Rosuvastatin works by blocking the enzyme HMG-CoA reductase, which plays a crucial role in the production of cholesterol in the liver. By inhibiting this enzyme, Rosuvastatin lowers LDL (bad cholesterol) levels and increases HDL (good cholesterol) levels, thus helping to maintain a healthier lipid profile.

Side Effects

Common side effects:

• Muscle pain or weakness
• Nausea
• Headache
• Abdominal discomfort

Rare/serious side effects:

• Severe muscle breakdown (rhabdomyolysis)
• Liver problems (indicated by yellowing of the skin or eyes)
• Kidney damage due to muscle breakdown

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Inform your doctor if you have liver disease, kidney problems, or a history of muscle disorders.
• Use caution if combining with other medications that may affect liver function.
• Regular blood tests may be required to monitor liver function and lipid levels.

Drug Interactions

May interact with:

• Gemfibrozil (may increase risk of muscle-related side effects)
• Anticoagulants (such as warfarin)
• Other medications that affect cholesterol levels (e.g., other statins)
• Certain antifungals or antibiotics

Always inform your healthcare provider about any other medications or supplements you are taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep in a dry place, away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Severe muscle pain
• Nausea or vomiting
• Dizziness
• Fatigue

Contact a poison control center or seek emergency medical help immediately if overdose is suspected.

Contraindications

• Allergic to Rosuvastatin or any of its components
• Active liver disease or unexplained persistent elevations in liver enzymes
• Pregnant or breastfeeding without medical advice

Brand Names / Alternatives

• Crestor
• Ezallor
• Generic name: Rosuvastatin