Avanafil

Description

Avanafil is a selective phosphodiesterase type 5 (PDE5) inhibitor primarily used to treat erectile dysfunction (ED). It works by enhancing blood flow to the penis during sexual stimulation, helping to achieve and maintain an erection. Avanafil is known for its rapid onset of action, often working within 15 to 30 minutes after ingestion.

Uses / Indications

• Erectile dysfunction (ED) in adult men
• Improvement of erectile function in men with varying degrees of ED
• Use in conjunction with sexual stimulation to enhance erection response

Dosage and Administration

Adults:
Take 100 mg approximately 15-30 minutes before sexual activity. Dose may be adjusted to 50 mg or 200 mg based on individual efficacy and tolerance, with a maximum recommended frequency of once per day.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Avanafil selectively inhibits the enzyme phosphodiesterase type 5 (PDE5), preventing the breakdown of cyclic guanosine monophosphate (cGMP). Elevated cGMP levels enhance smooth muscle relaxation and blood flow to the penis, facilitating an erection in response to sexual stimulation.

Side Effects

Common side effects:

• Headache
• Flushing (redness of the skin)
• Nasal congestion
• Back pain

Rare/serious side effects:

• Priapism (prolonged and painful erections)
• Sudden decrease or loss of vision
• Sudden decrease or loss of hearing
• Heart attack symptoms (e.g., chest pain, irregular heartbeat)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Tell your doctor if you have a history of heart problems, low blood pressure, or are taking medications for hypertension
• Use caution if combining with nitrates or other medications that lower blood pressure
• Not intended for use in women or children

Drug Interactions

May interact with:

• Nitrates (can cause severe hypotension)
• Other medications for erectile dysfunction (increased side effects)
• Alpha-blockers (risk of hypotension)
• CYP3A4 inhibitors (may increase avanafil levels in the body)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (15°C–30°C / 59°F–86°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Avanafil is taken as needed before sexual activity; therefore, a missed dose should not apply. Only take it as prescribed when planning sexual activity.

Overdose symptoms:

• Severe dizziness
• Prolonged erection (more than 4 hours)
• Nausea
• Palpitations

Contact a poison control center or seek emergency medical help immediately if an overdose is suspected.

Contraindications

• Allergic to Avanafil or any ingredient in the formulation
• Use of nitrates in any form
• Severe liver disease

Brand Names / Alternatives

• Stendra (brand name)
• Generic name: Avanafil