Fluoxetine

Description

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) commonly prescribed to treat a variety of mental health conditions. It helps increase the levels of serotonin, a neurotransmitter that plays a key role in mood regulation, thereby improving symptoms associated with depression and anxiety.

Uses / Indications

• Major depressive disorder
• Obsessive-compulsive disorder (OCD)
• Bulimia nervosa
• Panic disorder
• Premenstrual dysphoric disorder (PMDD)
• Chronic pain conditions (as an adjunct)

Dosage and Administration

Adults:
20 mg once daily (can be increased to a maximum of 80 mg, depending on doctor’s advice).

Children (ages 8-18):
10 mg once daily (may be adjusted based on response and tolerability).

Note: Dosage may vary based on medical condition or doctor’s recommendation.

How It Works (Mechanism of Action)

Fluoxetine selectively inhibits the reuptake of serotonin in the brain, leading to increased concentrations of serotonin in the synaptic cleft. This modulation of serotonin levels helps improve mood and alleviate symptoms of various mental health disorders.

Side Effects

Common side effects:

• Nausea
• Insomnia
• Dry mouth
• Dizziness
• Weight changes

Rare/serious side effects:

• Suicidal thoughts or behavior
• Serotonin syndrome (symptoms include agitation, hallucinations, fever)
• Severe allergic reactions (rash, swelling)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Tell your doctor if you have a history of liver disease, seizures, or bipolar disorder
• Use caution if combining with other medications that affect serotonin levels
• Monitor closely if pregnant or breastfeeding

Drug Interactions

May interact with:

• Other antidepressants (especially MAO inhibitors)
• Blood thinners (e.g., warfarin)
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Medications that affect liver enzymes

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Severe drowsiness
• Nausea and vomiting
• Rapid heartbeat
• Confusion

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to Fluoxetine or any inactive ingredients
• Use of MAO inhibitors within the past 14 days

Brand Names / Alternatives

• Prozac
• Sarafem
• Fluoxetine Hydrochloride (generic)