Sildenafil

Sildenafil 25mg, 50mg, 100mg

Sildenafil is a medication primarily used to treat erectile dysfunction by increasing blood flow to the penis, facilitating an erection in response to sexual stimulation. It works by inhibiting an enzyme called phosphodiesterase type 5 (PDE5), which leads to improved erectile function. Additionally, Sildenafil is also prescribed for pulmonary arterial hypertension to improve exercise capacity and hemodynamics in both men and women. It is essential to consult a healthcare provider before use to ensure safety and appropriate dosing.

Order Now

Description

Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor used primarily to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). It enhances blood flow to the penis during sexual stimulation, helping to achieve and maintain an erection. Additionally, it relaxes blood vessels in the lungs to improve exercise capacity in individuals with PAH.

Uses / Indications

Erectile dysfunction (impotence)
Pulmonary arterial hypertension (inhabitants with certain types of heart and lung conditions)
Improvement of exercise capacity in pulmonary hypertension patients

Dosage and Administration

Adults:
For erectile dysfunction: 50 mg taken as needed, approximately 1 hour before sexual activity. The dose may be adjusted between 25 mg and 100 mg based on efficacy and tolerability.

Pulmonary arterial hypertension:
20 mg taken three times a day, taken at approximately 4- to 6-hour intervals.

Note: Dosage may vary based on individual medical conditions and should be determined by a healthcare professional.

How It Works (Mechanism of Action)

Sildenafil works by selectively inhibiting the enzyme phosphodiesterase type 5 (PDE5), leading to increased levels of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. This causes relaxation of smooth muscle and dilation of blood vessels, facilitating enhanced blood flow and an erection in response to sexual stimulation.

Side Effects

Common side effects:

Headache
Flushing
Indigestion
Nasal congestion
Dizziness

Rare/serious side effects:

Vision changes (e.g., sudden blindness or blue-tinted vision)
Hearing loss
Priapism (painful erection lasting longer than 4 hours)
Severe allergic reactions (rash, swelling, difficulty breathing)

Seek medical attention if serious side effects occur.

Precautions / Warnings

Tell your doctor if you have heart disease, low blood pressure, or a history of strokes.
Use caution when taking with other medications that affect blood pressure.
Avoid using in conjunction with nitrates or other medications for chest pain.

Drug Interactions

May interact with:

Nitrates (may lead to dangerous decreases in blood pressure)
Certain antibiotics and antifungals
Alpha-blockers (may enhance blood pressure-lowering effects)
Other medications for erectile dysfunction

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

Store at room temperature (20°C–25°C / 68°F–77°F)
Keep away from moisture, heat, and direct light
Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next scheduled dose, skip the missed one. Do not double up.

Overdose symptoms:

Severe dizziness
Fainting
Prolonged erection (priapism)
Sudden vision loss

Contact a poison control center or seek emergency medical help immediately.

Contraindications

Allergic to Sildenafil or any of its components
Patients taking nitrates or other similar medications

Brand Names / Alternatives

Viagra
Revatio (for pulmonary hypertension)
Generic name: Sildenafil