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Domperidone

Domperidone 10mg, 20mg

Domperidone is a medication that acts as an antiemetic and prokinetic agent, primarily used to alleviate nausea and vomiting by blocking dopamine receptors in the gastrointestinal tract. It is often prescribed to manage symptoms related to various conditions, including gastroparesis and chemotherapy-induced nausea. Additionally, it can help improve gastric motility, making it useful for patients experiencing delayed stomach emptying.

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Description

Domperidone is a medication used primarily to relieve nausea and vomiting. It acts as a dopamine receptor antagonist, helping to increase the movement of food through the stomach and intestines, thereby alleviating discomfort and preventing feelings of nausea.

Uses / Indications

  • Nausea and vomiting associated with chemotherapy or surgery
  • Gastroparesis (delayed gastric emptying) in diabetic patients
  • Heartburn and gastroesophageal reflux disease (GERD)
  • Feeling of fullness or bloating after meals
  • Loss of appetite in chronic illness

Dosage and Administration

Adults:
Typically, 10 mg taken up to three times a day, 15 to 30 minutes before meals.

Children (based on weight):
0.25 mg/kg (up to 10 mg) taken three times daily before meals.

Note: Dosage may vary based on medical condition or doctor’s advice.

How It Works (Mechanism of Action)

Domperidone works by blocking D2 dopamine receptors in the gut and the chemoreceptor trigger zone (CTZ) in the brain, which helps to enhance gastric motility and decrease the sensation of nausea. Unlike some other medications, it tends to have minimal effects on the central nervous system due to its poor penetration of the blood-brain barrier.

Side Effects

Common side effects:

  • Dry mouth
  • Abdominal cramping
  • Headache
  • Diarrhea

Rare/serious side effects:

  • Cardiac arrhythmias (such as prolonged QT interval)
  • Severe allergic reactions (rash, swelling, difficulty breathing)
  • Extrapyramidal symptoms (movement disorders)

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Notify your doctor if you have a history of heart problems or are taking medications that affect heart rhythm
  • Use caution if combining with other medications that can cause drowsiness
  • This medication may not be recommended for individuals with significant liver impairment

Drug Interactions

Domperidone may interact with:

  • Other medications that affect heart rhythm
  • Certain antifungals and antibiotics (may impact metabolism)
  • Medications that cause sedation

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct light
  • Do not freeze the liquid form
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s close to the time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Severe drowsiness
  • Heart palpitations
  • Severe headache
  • Nausea and vomiting

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergic to Domperidone or any of its components
  • Severe liver disease
  • Existing heart issues, especially long QT syndrome

Brand Names / Alternatives

  • Motilium
  • Peridone
  • Domperon
  • Generic name: Domperidone