Fludrocortisone

Description

Fludrocortisone is a synthetic mineralocorticoid used primarily to treat conditions related to adrenal insufficiency, such as Addison’s disease. It works by mimicking the action of aldosterone, a hormone that helps regulate sodium and potassium levels in the body, subsequently influencing blood pressure and fluid balance.

Uses / Indications

• Adrenal insufficiency (Addison’s disease)
• Orthostatic hypotension (low blood pressure when standing)
• Congenital adrenal hyperplasia (CAH)
• Postural hypotension associated with certain medical conditions

Dosage and Administration

Adults:
The typical starting dose is 0.1 mg to 0.3 mg daily, taken orally. The dose may be adjusted as necessary to maintain the desired effect.

Children:
Dosage for children must be determined by a healthcare professional based on individual medical needs.

Note: Dosage may vary based on medical condition, age, and doctor’s advice.

How It Works (Mechanism of Action)

Fludrocortisone mimics the natural hormone aldosterone, promoting sodium reabsorption in the kidneys while facilitating potassium excretion. This action increases the retention of fluids, helping to maintain blood volume and blood pressure.

Side Effects

Common side effects:

• Weight gain
• Edema (swelling due to fluid retention)
• High blood pressure (hypertension)
• Headache

Rare/serious side effects:

• Severe allergic reactions (rash, itching, swelling)
• Heart problems (irregular heartbeat, palpitations)
• Signs of infection (fever, chills)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Inform your doctor if you have hypertension, heart disease, or kidney issues
• Use caution if pregnant or breastfeeding.
• Regular monitoring of blood pressure and electrolytes may be required.

Drug Interactions

May interact with:

• Other corticosteroids
• Diuretics (may increase potassium loss)
• Antidiabetic medications (may affect blood sugar levels)
• Medications affecting liver enzymes

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Severe headaches
• Puffiness or swelling
• High blood pressure symptoms (vision changes, severe headache)

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to Fludrocortisone or any of its components
• Untreated serious infections

Brand Names / Alternatives

• Florinef
• Generic name: Fludrocortisone