Fludrocortisone

Fludrocortisone 0.1mg

Fludrocortisone is a synthetic steroid used primarily to treat conditions related to adrenal insufficiency, such as Addison’s disease, by helping to maintain electrolyte balance and blood pressure. It works by mimicking the action of the hormone aldosterone, promoting sodium retention and potassium excretion in the kidneys. Fludrocortisone is often prescribed to enhance mineralocorticoid activity and is vital for patients requiring additional hormonal support.

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Description

Fludrocortisone is a synthetic corticosteroid primarily used for its anti-inflammatory and mineralocorticoid effects. It helps increase sodium retention in the kidneys, which in turn helps to maintain blood pressure and fluid balance in the body, making it an essential treatment for certain adrenal insufficiencies and other conditions.

Uses / Indications

Primary adrenal insufficiency (Addison’s disease)
Congenital adrenal hyperplasia
Orthostatic hypotension (low blood pressure upon standing)
Treatment of conditions that require additional mineralocorticoid activity
Part of replacement therapy for adrenal hormone deficiencies

Dosage and Administration

Adults:
Typically, 0.1 mg to 1 mg daily, depending on the condition being treated and the patient’s response. The dosage may be adjusted based on clinical response and electrolyte levels.

Children:
Dosage is usually tailored by a healthcare provider based on weight and response, often starting with lower doses.

Note: Dosage may vary based on medical condition, doctor’s advice, and patient response.

How It Works (Mechanism of Action)

Fludrocortisone mimics the effects of the natural hormone aldosterone by acting on the kidneys to promote sodium reabsorption and potassium excretion, which helps to increase blood volume and regulate blood pressure.

Side Effects

Common side effects:

Fluid retention and swelling
Increased blood pressure
Electrolyte imbalances (such as low potassium)
Headache

Rare/serious side effects:

Severe allergic reactions (rash, itching, swelling)
Signs of infection (fever, chills)
Adrenal suppression (especially with long-term use)

Immediate medical attention is advised if serious side effects occur.

Precautions / Warnings

Discuss with your doctor if you have a history of heart disease, hypertension, or liver problems.
Use caution if pregnant or breastfeeding and inform your healthcare provider.
Regular monitoring of blood pressure and electrolytes is typically recommended during treatment.

Drug Interactions

May interact with:

Certain diuretics (increased risk of electrolyte imbalances)
Anticoagulants (may affect blood clotting)
Vaccines (may decrease effectiveness)
Other steroids or medications that affect adrenal function

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

Store at room temperature (20°C–25°C / 68°F–77°F)
Keep away from moisture, heat, and direct light
Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

Severe fluid retention
High blood pressure
Severe headache
Nausea or vomiting

Contact a poison control center or seek emergency medical help immediately.

Contraindications

Hypersensitivity to fludrocortisone or any of its components
Systemic fungal infections
Untreated bacterial infections (unless adequately covered by antibiotics)

Brand Names / Alternatives

Florinef
Generic name: Fludrocortisone