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Pantoprazole

Pantoprazole 20mg, 40mg

Pantoprazole is a proton pump inhibitor (PPI) used to treat conditions related to excess stomach acid, such as gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome. By blocking the production of stomach acid, it helps alleviate symptoms such as heartburn and acid regurgitation, promoting healing of the esophagus and reducing the risk of damage from acidic irritants. Pantoprazole is typically taken orally and can be effective for long-term management of acid-related disorders.

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Description

Pantoprazole is a proton pump inhibitor (PPI) that is used to treat certain stomach and esophagus conditions. It works by decreasing the amount of acid produced in the stomach, providing relief from symptoms such as heartburn, difficulty swallowing, and persistent cough. By reducing stomach acid, Pantoprazole helps promote the healing of erosive esophagitis caused by gastroesophageal reflux disease (GERD).

Uses / Indications

  • Gastroesophageal reflux disease (GERD)
  • Erosive esophagitis due to acid-mediated damage
  • Zollinger-Ellison syndrome (excessive stomach acid production)
  • Prevention of gastric ulcers in patients taking NSAIDs (nonsteroidal anti-inflammatory drugs)
  • Management of conditions requiring long-term reduction of stomach acid

Dosage and Administration

Adults:
The typical dosage is 40 mg once daily, taken orally before a meal. Duration of treatment may vary based on the condition being treated.

Older adults and patients with liver problems:
Dosage adjustments may be necessary; consult your healthcare provider for guidance.

Note: Dosage may be adjusted based on individual response and doctor’s recommendations.

How It Works (Mechanism of Action)

Pantoprazole works by irreversibly inhibiting the proton pump in the stomach lining, which significantly reduces gastric acid secretion. This action helps alleviate symptoms associated with excessive stomach acid production and assists in the healing of ulcerated tissue.

Side Effects

Common side effects:

  • Headaches
  • Nausea and vomiting
  • Diarrhea
  • Stomach pain
  • Flatulence

Rare/serious side effects:

  • Severe allergic reactions (rash, itching, swelling)
  • Kidney problems (such as low urine output)
  • Bone fractures (with prolonged use)

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor if you have liver disease or are pregnant/breastfeeding
  • Use with caution if taking other medications that affect liver enzymes
  • Long-term use may increase the risk of certain infections or nutrient deficiencies (e.g., magnesium)

Drug Interactions

May interact with:

  • Warfarin (may affect blood clotting)
  • Certain antifungal medications (e.g., ketoconazole)
  • Other drugs that reduce stomach acid (may reduce effectiveness)

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture and direct light
  • Do not freeze
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Severe dizziness
  • Confusion
  • Rapid heart rate
  • Severe abdominal cramps

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergic to Pantoprazole or any of its components
  • History of severe reactions to PPIs

Brand Names / Alternatives

  • Protonix
  • Pantoloc
  • Tecta
  • Generic name: Pantoprazole