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Rabeprazole

Rabeprazole 20mg, 40mg

Rabeprazole is a proton pump inhibitor (PPI) that reduces stomach acid production, effectively treating conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers. By inhibiting the proton pump in the stomach lining, it helps to alleviate symptoms like heartburn and acid reflux, promoting healing in the esophagus and stomach. Rabeprazole is commonly prescribed for both short-term and long-term management of acid-related disorders, offering a significant reduction in acid-related discomfort for many patients.

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Description

Rabeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is commonly used to treat various gastrointestinal conditions, helping to alleviate symptoms associated with excessive stomach acid production and providing healing effects for the esophagus.

Uses / Indications

  • Gastroesophageal reflux disease (GERD)
  • Erosive esophagitis caused by acid reflux
  • Stomach ulcers
  • Helicobacter pylori eradication (in combination with antibiotics)
  • Zollinger-Ellison syndrome (a condition that causes excessive stomach acid production)

Dosage and Administration

Adults:
20 mg once daily (may vary depending on the specific condition being treated)

For Helicobacter pylori eradication:
Typically, 20 mg twice daily for 7 days in combination with appropriate antibiotics.

Note: Dosage may be adjusted based on your healthcare provider’s recommendations.

How It Works (Mechanism of Action)

Rabeprazole works by inhibiting the proton pump in the stomach lining, effectively reducing gastric acid secretion. This helps heal and prevent the recurrence of ulcers and reduces symptom severity associated with acid-related disorders.

Side Effects

Common side effects:

  • Headache
  • Diarrhea
  • Nausea or vomiting
  • Abdominal pain

Rare/serious side effects:

  • Severe allergic reactions (rash, itching, swelling)
  • Liver damage (elevated liver enzymes)
  • Clostridium difficile infection in the colon

Contact your healthcare provider if you experience serious side effects.

Precautions / Warnings

  • Inform your doctor if you have liver disease or are pregnant/breastfeeding
  • Use with caution in elderly patients or those with a history of osteoporosis
  • Long-term use may increase the risk of certain infections or fractures

Drug Interactions

Rabeprazole may interact with:

  • Certain antifungal medications (e.g., ketoconazole)
  • Warfarin and other anticoagulants
  • Digoxin
  • Medications that require an acidic gastric environment for absorption

Always inform your healthcare provider about any medications or supplements you’re currently taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct sunlight
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Severe drowsiness
  • Confusion or disorientation
  • Fast heartbeat
  • Nausea or vomiting

Seek immediate medical attention if an overdose is suspected.

Contraindications

  • Allergic to Rabeprazole or other PPIs
  • Severe liver impairment (consult your doctor)

Brand Names / Alternatives

  • AcipHex
  • Generic name: Rabeprazole