Sevelamer

Description

Sevelamer is a phosphate binder used primarily to control serum phosphate levels in patients with chronic kidney disease (CKD) who are on dialysis. It helps prevent the absorption of dietary phosphate, thereby aiding in the management of hyperphosphatemia, a common complication in patients with impaired kidney function.

Uses / Indications

• Chronic kidney disease (CKD) on dialysis
• Hyperphosphatemia in patients with end-stage renal disease
• Management of serum phosphorus levels in patients with kidney dysfunction

Dosage and Administration

Adults:
The recommended starting dose is typically 800 mg to 1600 mg taken with meals, adjusted based on serum phosphorus levels.

Pediatric population:
Safety and effectiveness in children have not been established; dosing should be determined by a healthcare professional.

Note: Dosage may vary based on individual medical conditions and doctor’s recommendations.

How It Works (Mechanism of Action)

Sevelamer works by binding to dietary phosphate in the gastrointestinal tract, preventing its absorption into the bloodstream. This action helps lower elevated phosphate levels without causing calcium imbalances, making it particularly beneficial for patients with renal impairment.

Side Effects

Common side effects:

• Nausea
• Vomiting
• Diarrhea
• Constipation

Rare/serious side effects:

• Bowel obstruction
• Severe gastrointestinal discomfort
• Allergic reactions (rash, itching, swelling)

Seek medical attention if serious side effects occur.

Precautions / Warnings

• Discuss with your doctor if you have gastrointestinal disorders or bowel obstruction issues.
• Monitor for potential vitamin deficiencies, especially fat-soluble vitamins.
• Use with caution if you are pregnant or breastfeeding.

Drug Interactions

May interact with:

• Ciprofloxacin (may reduce absorption)
• Vitamin D and other supplements (may impact absorption)
• Medications requiring phosphate for efficacy

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

• Store at room temperature (20°C–25°C / 68°F–77°F)
• Keep away from moisture, heat, and direct light
• Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember, but if it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

• Severe gastrointestinal distress
• Abdominal pain or bloating
• Constipation

Contact a poison control center or seek emergency medical help immediately.

Contraindications

• Allergic to Sevelamer or any component of the formulation
• Bowel obstruction

Brand Names / Alternatives

• Renvela
• Renagel
• Generic name: Sevelamer Carbonate