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Dutasteride

Dutasteride 0.5mg

Dutasteride is a medication primarily used to treat benign prostatic hyperplasia (BPH) in men by inhibiting the conversion of testosterone to dihydrotestosterone (DHT), a hormone that contributes to prostate growth. By reducing DHT levels, Dutasteride helps alleviate urinary symptoms associated with an enlarged prostate, such as difficulty in urination and an increased need to urinate. It is also sometimes used off-label for promoting hair growth in men with androgenetic alopecia.

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Description

Dutasteride is a medication primarily used to treat benign prostatic hyperplasia (BPH) in men. It functions by inhibiting the conversion of testosterone to dihydrotestosterone (DHT), a hormone responsible for prostate growth. By reducing DHT levels, Dutasteride helps alleviate urinary symptoms associated with an enlarged prostate.

Uses / Indications

  • Benign prostatic hyperplasia (BPH)
  • Management of urinary symptoms such as difficulty urinating, increased frequency, and urgency
  • Off-label use in androgenetic alopecia (hair loss in men)

Dosage and Administration

Adults:
0.5 mg once daily, taken orally with or without food.

Note: Dosage may vary based on individual circumstances and doctor’s recommendations.

How It Works (Mechanism of Action)

Dutasteride inhibits the activity of both Type I and Type II 5-alpha reductase enzymes, leading to a significant decrease in DHT levels in the body. This reduction in DHT helps shrink the prostate gland and improve urinary flow in men experiencing symptoms of BPH.

Side Effects

Common side effects:

  • Decreased libido
  • Ejaculation disorders
  • Breast tenderness or enlargement
  • Fatigue

Rare/serious side effects:

  • Allergic reactions (rash, itching, swelling)
  • Signs of liver issues (dark urine, jaundice)
  • High-grade prostate cancer (the risk should be discussed with your doctor)

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor if you have liver disease or are planning to father a child
  • Caution is advised if taking other medications that affect liver function
  • Women who are or may become pregnant should avoid handling Dutasteride capsules

Drug Interactions

Dutasteride may interact with:

  • Cyclosporine (may increase blood levels of cyclosporine)
  • Medications that affect liver enzymes (e.g., rifampicin)
  • Other medications affecting hormone levels

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s close to the time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Signs of liver problems (such as jaundice)
  • Severe dizziness or fainting
  • Abnormal breast growth or tenderness

Contact a poison control center or seek emergency medical help immediately if an overdose is suspected.

Contraindications

  • Allergy to Dutasteride or any inactive ingredients
  • Pregnant or breastfeeding women

Brand Names / Alternatives

  • Avodart
  • Generic name: Dutasteride