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Baclofen

Baclofen 10mg, 20mg, 25mg, 30mg

Baclofen is a muscle relaxant and antispastic agent primarily used to manage spasticity and muscle tightness resulting from conditions such as multiple sclerosis and spinal cord injuries. It works by acting on the central nervous system to inhibit nerve signals, thereby reducing muscle spasms and stiffness. Baclofen can also be prescribed for managing certain types of pain and may help improve mobility and overall quality of life in patients with neurological disorders.

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Description

Baclofen is a muscle relaxant that works by affecting the central nervous system to relieve muscle spasms and stiffness. It is commonly prescribed for conditions that involve muscle tightness and spasticity, providing relief by acting as an agonist at the GABA-B receptor, which helps relax muscles and reduce pain.

Uses / Indications

  • Muscle spasms associated with multiple sclerosis
  • Spasticity resulting from spinal cord injuries or diseases
  • Muscle stiffness related to cerebral palsy
  • Management of severe muscle rigidity in neurological conditions
  • Adjunct treatment for pain related to severe spasticity

Dosage and Administration

Adults:
Initial dose is typically 5 mg three times a day; may be increased based on tolerance and therapeutic effect.

Children aged 8 years and older:
Initial dose is usually 5 mg three times a day, with careful monitoring for effectiveness and side effects.

Note: Dosage may vary based on individual needs and doctor’s advice.

How It Works (Mechanism of Action)

Baclofen acts primarily as a selective GABA-B receptor agonist, enhancing inhibitory neurotransmission in the central nervous system. This leads to decreased excitatory signals, resulting in reduced muscle tone and spasticity, thereby alleviating associated discomfort.

Side Effects

Common side effects:

  • Drowsiness
  • Dizziness
  • Weakness
  • Nausea

Rare/serious side effects:

  • Severe allergic reactions (rash, itching, swelling)
  • Confusion or hallucinations
  • Severe muscle weakness

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor if you have kidney problems, seizures, or a history of substance abuse
  • Caution advised when operating heavy machinery as Baclofen may cause drowsiness
  • Gradually discontinue use to avoid withdrawal symptoms

Drug Interactions

May interact with:

  • Alcohol (may enhance sedative effects)
  • Other central nervous system depressants (opioids, benzodiazepines)
  • Antidepressants or medications that affect serotonin levels
  • Diuretics (may exacerbate muscle cramps)

Always inform your healthcare provider about any other medications or supplements you are taking.

Storage Instructions

  • Store at room temperature (20°C–25°C / 68°F–77°F)
  • Keep away from moisture, heat, and direct light
  • Do not freeze liquid forms
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose. Do not double up.

Overdose symptoms:

  • Severe drowsiness
  • Slow or shallow breathing
  • Loss of consciousness
  • Hypotonia (extreme muscle weakness)

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergic to Baclofen
  • Severe renal impairment

Brand Names / Alternatives

  • Kemstro
  • Lioresal
  • Baclofen (generic)
  • Baclofen Intrathecal (for specific cases)