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Nimodipine

Nimodipine 30mg

Nimodipine is a calcium channel blocker primarily used to improve outcomes in patients with subarachnoid hemorrhage, a type of bleeding in the brain. By relaxing blood vessels and increasing blood flow to the brain, it helps prevent complications such as vasospasm, which can lead to further neurological damage. Nimodipine is typically administered orally and is considered crucial for enhancing recovery and reducing the risk of long-term disability following cerebral hemorrhage.

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Description

Nimodipine is a calcium channel blocker primarily used to prevent and treat complications associated with subarachnoid hemorrhage (SAH), particularly vasospasm in patients. By relaxing the blood vessels and increasing blood flow to the brain, it helps mitigate neurological damage that may occur after bleeding in the brain.

Uses / Indications

  • Prevention of cerebral vasospasm following subarachnoid hemorrhage
  • Improving blood flow and oxygen delivery to brain tissue
  • Management of specific forms of angina pectoris
  • Adjunct treatment in certain neurological disorders

Dosage and Administration

Adults:
Typically, 30 mg every 4 hours for 21 consecutive days starting within 96 hours after the onset of SAH. Administered orally.

Not recommended for children:
Use in pediatric populations has not been established; consult a healthcare provider for guidance.

Note: Dosage may vary based on individual patient conditions and physician recommendations.

How It Works (Mechanism of Action)

Nimodipine selectively inhibits calcium influx through L-type calcium channels in the smooth muscle of cerebral blood vessels. This action relaxes the blood vessels, leading to increased cerebral blood flow and the prevention of vasospasm following subarachnoid hemorrhage.

Side Effects

Common side effects:

  • Headache
  • Nausea
  • Hypotension (low blood pressure)
  • Dizziness or lightheadedness

Rare/serious side effects:

  • Severe allergic reactions (rash, itching, swelling)
  • Rapid heartbeat
  • Loss of consciousness or fainting

Seek medical attention if serious side effects occur.

Precautions / Warnings

  • Inform your doctor if you have a history of heart disease or low blood pressure
  • Use with caution in patients with hepatic impairment
  • Avoid alcohol as it may exacerbate side effects

Drug Interactions

May interact with:

  • Other antihypertensive agents
  • Certain antibiotics (e.g., erythromycin)
  • Antifungal medications (e.g., ketoconazole)
  • Medications that affect liver enzymes

Always inform your healthcare provider about any other medications or supplements you’re taking.

Storage Instructions

  • Store at room temperature (15°C–30°C / 59°F–86°F)
  • Keep away from moisture, heat, and direct light
  • Keep out of reach of children

Missed Dose / Overdose

Missed a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double up.

Overdose symptoms:

  • Severe drop in blood pressure
  • Rapid or irregular heartbeat
  • Fainting
  • Confusion or altered consciousness

Contact a poison control center or seek emergency medical help immediately.

Contraindications

  • Allergy to Nimodipine or any of its components
  • Severe hypotension or cardiovascular disease that may be exacerbated by vasodilation

Brand Names / Alternatives

  • Nimotop
  • Generic name: Nimodipine